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Detail předmětu
FEKT-MPAN-TBIAk. rok: 2026/2027
The course introduces students to the methods, technologies, and instrumentation used in the fields of cell and tissue engineering in laboratories and research. This course provides a comprehensive overview of the principles and methodologies of cell and tissue engineering with a focus on applications in regenerative medicine. It covers the basics of biomaterials used in tissue engineering, scaffold design and fabrication, cell culture techniques, and the use of bioreactors. The course also includes the role of stem cells, mechanotransduction processes, and strategies for engineering vascular, skin, bone, and cartilage tissues, as well as organ-on-a-chip systems. Emphasis is placed on cell-biomaterial interactions, advanced techniques for characterization of biomaterials and cells, and clinical translation of engineered tissues, including regulatory and ethical aspects.
Jazyk výuky
Počet kreditů
Garant předmětu
Zajišťuje ústav
Pravidla hodnocení a ukončení předmětu
The final grade for the course will be determined by the scores obtained from the midterm tests and the activity exercises (max. 20 points in total) and the final written examination (max. 80 points). Only students who have been awarded credit may take the final exam. - obtaining at least 15 points in the laboratory exercises, including points for the continuous written tests,- a non-zero score on the continuous written tests,- a non-zero score on the protocols or homework assignments,- meeting full attendance requirements.More detailed conditions for successful completion of the course are set out in the annually updated decree of the course coordinator.
Učební cíle
Základní literatura
Zařazení předmětu ve studijních plánech
specializace MPC-BIO_TECH , 2 ročník, letní semestr, povinně volitelný
Přednáška
Vyučující / Lektor
Osnova
1. Cell and Tissue Engineering Fundamentals2. Biomaterials in Tissue Engineering3. Scaffold Design & Fabrication for Tissue Engineering4. Cell Culture Techniques & Bioreactors5. Stem Cells in Regenerative Medicine6. Mechanotransduction in Cell Engineering7. Blood Vessel and Skin Tissue Engineering8. Bone and Cartilage Tissue Engineering9. Organ–on–a–Chip Systems10. Cell-biomaterial Interaction and Characterization11. Characterization Techniques of Biomaterials and Cells12. Clinical Translation & Regulatory Aspects
Laboratorní cvičení
1. Cultivation of cells. Preparation of hydrogel and seeding of cells on hydrogel. Degradation of hydrogel.2. Swelling of hydrogel. Evaluation of hydrogel swelling and degradation. Microscopic evaluation of cells on hydrogel (VIS, fluorescence).3. Basic of Fusion 360. Virtual reality for Fusion model. 3D printing and segmentation (Slicer) in cardiology + practical 3D printing.
Individuální příprava na laboratoře
Students are provided with prepared study materials for each laboratory. They are expected to study these materials independently in advance and, if necessary, look for additional information in lecture presentations or use other sources.
Individuální příprava na závěrečnou zkoušku