Detail publikace

Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

M Nováková, J Bardoňová, I Provazník

Originální název

Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in the first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol.

Klíčová slova

sigma receptor, haloperidol, isolated heart, electrogram

Autoři

M Nováková, J Bardoňová, I Provazník

Rok RIV

2006

Vydáno

17. 9. 2006

Nakladatel

IEEE

Místo

Valencia

ISBN

0-7803-8894-1

Kniha

Computers in Cardiology 2006

Strany od

1

Strany do

4

Strany počet

4

BibTex

@inproceedings{BUT19365,
  author="Marie {Nováková} and Jana {Kolářová} and Valentine {Provazník}",
  title="Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram",
  booktitle="Computers in Cardiology 2006",
  year="2006",
  volume="2006",
  pages="4",
  publisher="IEEE",
  address="Valencia",
  isbn="0-7803-8894-1"
}