Detail publikačního výsledku

Network Analysis of Proteins Associated with Schizophrenia

MUSILOVÁ, J.; KOŠČOVÁ, P.

Originální název

Network Analysis of Proteins Associated with Schizophrenia

Anglický název

Network Analysis of Proteins Associated with Schizophrenia

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

The aim of this study is a network analysis of proteins ADRA1A, DRD1, DRD2 and HTR2A associated with a schizophrenia disease. By random graph analysis, all researched proteins were evaluated as significant. Using Cytoscape software, significant DPI (drug-protein interactions), PPI (protein-protein interactions) and pathways were revealed. By historeceptomics analysis, significant regions in amygdala, smooth muscle or spinal cord and prefrontal cortex were identified. The acquired knowledge can contribute to further research in the development of multitarget drugs against schizophrenia disease.

Anglický abstrakt

The aim of this study is a network analysis of proteins ADRA1A, DRD1, DRD2 and HTR2A associated with a schizophrenia disease. By random graph analysis, all researched proteins were evaluated as significant. Using Cytoscape software, significant DPI (drug-protein interactions), PPI (protein-protein interactions) and pathways were revealed. By historeceptomics analysis, significant regions in amygdala, smooth muscle or spinal cord and prefrontal cortex were identified. The acquired knowledge can contribute to further research in the development of multitarget drugs against schizophrenia disease.

Klíčová slova

Network Analysis, PPI, Schizophrenia

Klíčová slova v angličtině

Network Analysis, PPI, Schizophrenia

Autoři

MUSILOVÁ, J.; KOŠČOVÁ, P.

Rok RIV

2019

Vydáno

26.04.2018

Místo

Brno

ISBN

978-80-214-5614-3

Kniha

Proceedings of the 24rd Conference STUDENT EEICT 2018

Strany od

273

Strany do

275

Strany počet

3

BibTex

@inproceedings{BUT147250,
  author="Jana {Musilová} and Pavlína {Cicková}",
  title="Network Analysis of Proteins Associated with Schizophrenia",
  booktitle="Proceedings of the 24rd Conference STUDENT EEICT 2018",
  year="2018",
  pages="273--275",
  address="Brno",
  isbn="978-80-214-5614-3"
}