Detail publikačního výsledku

Revisiting lab-on-a-chip technology for drug discovery

NEUŽIL, P., GISELBRECHT, S., LANGE, K., HUANG, TJ., MANZ, A.

Originální název

Revisiting lab-on-a-chip technology for drug discovery

Anglický název

Revisiting lab-on-a-chip technology for drug discovery

Druh

Článek WoS

Originální abstrakt

The field of microfluidics or lab-on-a-chip technology aims to improve and extend the possibilities of bioassays, cell biology and biomedical research based on the idea of miniaturization. Microfluidic systems allow more accurate modelling of physiological situations for both fundamental research and drug development, and enable systematic high-volume testing for various aspects of drug discovery. Microfluidic systems are in development that not only model biological environments but also physically mimic biological tissues and organs; such 'organs on a chip' could have an important role in expediting early stages of drug discovery and help reduce reliance on animal testing. This Review highlights the latest lab-on-a-chip technologies for drug discovery and discusses the potential for future developments in this field.

Anglický abstrakt

The field of microfluidics or lab-on-a-chip technology aims to improve and extend the possibilities of bioassays, cell biology and biomedical research based on the idea of miniaturization. Microfluidic systems allow more accurate modelling of physiological situations for both fundamental research and drug development, and enable systematic high-volume testing for various aspects of drug discovery. Microfluidic systems are in development that not only model biological environments but also physically mimic biological tissues and organs; such 'organs on a chip' could have an important role in expediting early stages of drug discovery and help reduce reliance on animal testing. This Review highlights the latest lab-on-a-chip technologies for drug discovery and discusses the potential for future developments in this field.

Klíčová slova

HIGH-THROUGHPUT ANALYSIS; STEM-CELL NICHES; MICROFLUIDIC DEVICE; CAENORHABDITIS-ELEGANS; FEMTOLITER-VOLUME; PICOLITER-VOLUME; ANALYSIS SYSTEMS; MAMMALIAN-CELLS; SINGLE-CELLS; DROPLETS

Klíčová slova v angličtině

HIGH-THROUGHPUT ANALYSIS; STEM-CELL NICHES; MICROFLUIDIC DEVICE; CAENORHABDITIS-ELEGANS; FEMTOLITER-VOLUME; PICOLITER-VOLUME; ANALYSIS SYSTEMS; MAMMALIAN-CELLS; SINGLE-CELLS; DROPLETS

Autoři

NEUŽIL, P., GISELBRECHT, S., LANGE, K., HUANG, TJ., MANZ, A.

Rok RIV

2013

Vydáno

30.08.2012

Nakladatel

NATURE PUBLISHING GROUP,

Místo

MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND

ISSN

1474-1776

Periodikum

NATURE REVIEWS DRUG DISCOVERY

Svazek

2012 (11)

Číslo

8

Stát

Spojené království Velké Británie a Severního Irska

Strany od

620

Strany do

632

Strany počet

13

BibTex

@article{BUT98592,
  author="Pavel {Neužil}",
  title="Revisiting lab-on-a-chip technology for drug discovery",
  journal="NATURE REVIEWS DRUG DISCOVERY",
  year="2012",
  volume="2012 (11)",
  number="8",
  pages="620--632",
  doi="10.1038/nrd3799",
  issn="1474-1776"
}