Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs

Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs

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Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.

Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.

aerosol transport, aerosol deposition, positron emission tomography, human lung model

aerosol transport, aerosol deposition, positron emission tomography, human lung model

LÍZAL, F.; JEDELSKÝ, J.; ADAM, J.; BĚLKA, M.; JÍCHA, M.

2013

09.04.2013

EDP Sciences

Francie

978-80-7372-912-7

EPJ Web of Conferences

2100-014X

EPJ Web of Conferences

45

1

Francouzská republika

1

4

4

https://www.epj-conferences.org/articles/epjconf/abs/2013/06/epjconf_efm2013_01060/epjconf_efm2013_01060.html

http://hdl.handle.net/11012/193652

epjconf_efm2013_01060