Detail publikačního výsledku

FE models of stress-strain states in vascular smooth muscle cell

BURŠA, J.; LEBIŠ, R.; JANÍČEK, P.

Originální název

FE models of stress-strain states in vascular smooth muscle cell

Anglický název

FE models of stress-strain states in vascular smooth muscle cell

Druh

Článek recenzovaný mimo WoS a Scopus

Originální abstrakt

The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of computational modelling of SMCs under physiological load are discussed.

Anglický abstrakt

The paper deals with problems related to computational modelling of stress-strain states in vascular smooth muscle cells (SMCs). First, motivation for stress-strain analysis of SMCs is presented. Problems of their structure, geometry, constitutive models and initial (stress-free) state are analyzed on the basis of anatomical, histological and physiological knowledge. Various types of computational FE models of SMCs are presented; their constitutive models are identified on the basis of published mechanical tests carried out with SMCs cultured in vitro. Results of two models are presented; the former is a homogeneous model of the cell tension test with hyperelastic constitutive relations of the cell material. The latter model is more complex, it comprehends cortical and deep cytoskeleton, modelled as a tensegrity structure, and homogeneous linear elastic nucleus and remaining cytoplasm; it is used in computational modelling of indentation test. Perspectives, assumptions and limitations of computational modelling of SMCs under physiological load are discussed.

Klíčová slova

smooth muscle cell, finite element method, tensegrity, mechanical test, computational simulation

Klíčová slova v angličtině

smooth muscle cell, finite element method, tensegrity, mechanical test, computational simulation

Autoři

BURŠA, J.; LEBIŠ, R.; JANÍČEK, P.

Vydáno

10.10.2006

Nakladatel

IOS Press

Místo

Nieuwe Hemweg 6B, 1013 BG, The Netherlands

ISSN

0928-7329

Periodikum

TECHNOLOGY AND HEALTH CARE

Svazek

14

Číslo

4,5

Stát

Nizozemsko

Strany od

311

Strany do

320

Strany počet

10

BibTex

@article{BUT43914,
  author="Jiří {Burša} and Radek {Lebiš} and Přemysl {Janíček}",
  title="FE models of stress-strain states in vascular smooth muscle cell",
  journal="TECHNOLOGY AND HEALTH CARE",
  year="2006",
  volume="14",
  number="4,5",
  pages="311--320",
  issn="0928-7329"
}