Wound dressing composed of nanofibrous polymer mats with natural antimicrobial agent

Wound dressing composed of nanofibrous polymer mats with natural antimicrobial agent

Funkční vzorek

The functional sample represents the wound dressing that is composed of: 1. polycaprolactone (PCL) nanofibrous mat, 2. its plasma-chemically modified top surface, 3. immobilized nano or microparticles of natural origin, exhibiting antimicrobial properties. An essential part of the wound dressing is PCL nanofibrous (NF) mat that is proposed as the starting materials of the wound dressing solution because of its excellent properties towards such application. We chosen electrospinning for the preparation of Functional Sample. We proved that plasma modification of PCL nanofibrous mats is an efficient method for immobilizing various nano and macroparticles made of natural materials on the mats. Depending on the type of particles, the optimized plasma modification has to be chosen. We concluded that O2 plasma treatment should not be used for 15 and 50 nm lignin NPs. Instead, amine PP coating was very successful. Vice versa, O2 plasma treatment was the method of choice for mycelium microparticles, another type of natural-origin antimicrobial agent. The differences between different plasma modification approaches were weak for other lignin-based particle types.

The functional sample represents the wound dressing that is composed of: 1. polycaprolactone (PCL) nanofibrous mat, 2. its plasma-chemically modified top surface, 3. immobilized nano or microparticles of natural origin, exhibiting antimicrobial properties. An essential part of the wound dressing is PCL nanofibrous (NF) mat that is proposed as the starting materials of the wound dressing solution because of its excellent properties towards such application. We chosen electrospinning for the preparation of Functional Sample. We proved that plasma modification of PCL nanofibrous mats is an efficient method for immobilizing various nano and macroparticles made of natural materials on the mats. Depending on the type of particles, the optimized plasma modification has to be chosen. We concluded that O2 plasma treatment should not be used for 15 and 50 nm lignin NPs. Instead, amine PP coating was very successful. Vice versa, O2 plasma treatment was the method of choice for mycelium microparticles, another type of natural-origin antimicrobial agent. The differences between different plasma modification approaches were weak for other lignin-based particle types.

polymer nanofibers; plasma treatment; lignin particles

polymer nanofibers; plasma treatment; lignin particles

RG Plasma Technologies, CEITEC VUT

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