Detail publikačního výsledku

Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering

HAVLÍKOVÁ, T.; PAPEŽ, N.; FOHLEROVÁ, Z.; KASPAR, P.; DALLAEV, R.; ČÁSTKOVÁ, K.; ŢĂLU, Ş.

Originální název

Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering

Anglický název

Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering

Druh

Článek WoS

Originální abstrakt

This study focused on the development of a suitable synthetic polymer scaffold for bone tissue engineering applications within the biomedical field. The investigation centered on electrospun polyvinylidene fluoride (PVDF) nanofibers, examining their intrinsic properties and biocompatibility with the human osteosarcoma cell line Saos-2. The influence of oxygen, argon, or combined plasma treatment on the scaffold’s characteristics was explored. A comprehensive design strategy is outlined for the fabrication of a suitable PVDF scaffold, encompassing the optimization of electrospinning parameters with rotating collector and plasma etching conditions to facilitate a subsequent osteoblast cell culture. The proposed methodology involves the fabrication of the PVDF tissue scaffold, followed by a rigorous series of fundamental analyses encompassing the structural integrity, chemical composition, wettability, crystalline phase content, and cell adhesion properties.

Anglický abstrakt

This study focused on the development of a suitable synthetic polymer scaffold for bone tissue engineering applications within the biomedical field. The investigation centered on electrospun polyvinylidene fluoride (PVDF) nanofibers, examining their intrinsic properties and biocompatibility with the human osteosarcoma cell line Saos-2. The influence of oxygen, argon, or combined plasma treatment on the scaffold’s characteristics was explored. A comprehensive design strategy is outlined for the fabrication of a suitable PVDF scaffold, encompassing the optimization of electrospinning parameters with rotating collector and plasma etching conditions to facilitate a subsequent osteoblast cell culture. The proposed methodology involves the fabrication of the PVDF tissue scaffold, followed by a rigorous series of fundamental analyses encompassing the structural integrity, chemical composition, wettability, crystalline phase content, and cell adhesion properties.

Klíčová slova

biocompatibility; bone tissue engineering; bone regeneration; cell–substrate interactions; electrospinning; nanofiber fabrication; osteoblasts; piezoelectric polymer; plasma treatment; polyvinylidene fluoride; scaffold

Klíčová slova v angličtině

biocompatibility; bone tissue engineering; bone regeneration; cell–substrate interactions; electrospinning; nanofiber fabrication; osteoblasts; piezoelectric polymer; plasma treatment; polyvinylidene fluoride; scaffold

Autoři

HAVLÍKOVÁ, T.; PAPEŽ, N.; FOHLEROVÁ, Z.; KASPAR, P.; DALLAEV, R.; ČÁSTKOVÁ, K.; ŢĂLU, Ş.

Vydáno

25.01.2025

Nakladatel

MDPI

Místo

BASEL

ISSN

2073-4360

Periodikum

Polymers

Svazek

17

Číslo

3

Stát

Švýcarská konfederace

Strany počet

23

URL

https://www.mdpi.com/2073-4360/17/3/330

Plný text v Digitální knihovně

http://hdl.handle.net/11012/255386

BibTex

@article{BUT196640,
  author="Tereza {Havlíková} and Nikola {Papež} and Zdenka {Fohlerová} and Pavel {Kaspar} and Rashid {Dallaev} and Klára {Částková} and Ştefan {Ţălu}",
  title="Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering",
  journal="Polymers",
  year="2025",
  volume="17",
  number="3",
  pages="23",
  doi="10.3390/polym17030330",
  url="https://www.mdpi.com/2073-4360/17/3/330"
}

Dokumenty

polymers-17-00330-v2