Detail publikačního výsledku

Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold

SMOLNICKÁ, A.; LIPOVÝ, B.; PAVLIŇÁKOVÁ, V.; HOLOUBEK, J.; FALDYNA, M.; JEKLOVÁ, E.; VOJTOVÁ, L.; KOUTNÁ, I.

Originální název

Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold

Anglický název

Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold

Druh

Abstrakt

Originální abstrakt

It has been proved that cellular skin substitutes provide faster wound healing and vascularization. Suitable cells for skin substitutes are mesenchymal stromal cells (MSCs), which have anti-inflammatory properties, appropriate differentiation capacity, and promote angiogenesis. MSCs can be differentiated into fibroblasts or preadipocytes. These differentiated cells were seeded on biocompatible and biodegradable collagen-chitosan foams that serve as scaffolds. Fibroblasts cultivated in the scaffold mimic the dermis layer, and preadipocytes imitate the hypodermis. Isolated keratinocytes were seeded on top of the scaffold as an epidermis layer.

Anglický abstrakt

It has been proved that cellular skin substitutes provide faster wound healing and vascularization. Suitable cells for skin substitutes are mesenchymal stromal cells (MSCs), which have anti-inflammatory properties, appropriate differentiation capacity, and promote angiogenesis. MSCs can be differentiated into fibroblasts or preadipocytes. These differentiated cells were seeded on biocompatible and biodegradable collagen-chitosan foams that serve as scaffolds. Fibroblasts cultivated in the scaffold mimic the dermis layer, and preadipocytes imitate the hypodermis. Isolated keratinocytes were seeded on top of the scaffold as an epidermis layer.

Klíčová slova

collagen, chitosan, scaffold, dermis, regenerative medicine

Klíčová slova v angličtině

collagen, chitosan, scaffold, dermis, regenerative medicine

Autoři

SMOLNICKÁ, A.; LIPOVÝ, B.; PAVLIŇÁKOVÁ, V.; HOLOUBEK, J.; FALDYNA, M.; JEKLOVÁ, E.; VOJTOVÁ, L.; KOUTNÁ, I.

Vydáno

25.04.2024

Místo

Praha

ISBN

978-80-01-07293-6

Kniha

Bioimplantologie a regenerativní medicína 2024

Strany od

45

Strany do

45

Strany počet

59

URL

https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d

BibTex

@misc{BUT189768,
  author="Anna {Smolnická} and Břetislav {Lipový} and Veronika {Pavliňáková} and Jakub {Holoubek} and Martin {Faldyna} and Edita {Jeklová} and Lucy {Vojtová} and Irena {Koutná}",
  title="Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold",
  booktitle="Bioimplantologie a regenerativní medicína 2024",
  year="2024",
  edition="1. elektronické",
  pages="45--45",
  address="Praha",
  isbn="978-80-01-07293-6",
  url="https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d",
  note="Abstract"
}