Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Článek WoS

Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image

Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image

non-fullerene acceptors; organic bioelectronics; photo-stimulation

non-fullerene acceptors; organic bioelectronics; photo-stimulation

Savva, A.; Hama, A.; Herrera-López, G.; Schmidt, T.; Migliaccio, L.; Steiner, N.; Kawan, M.; Fiumelli, H.; Magistretti, PJ.; Mcculloch, I.; Baran, D.; Gasparini, N.; Schindl, R.; Glowacki, ED.; Inal, S.

2024

03.11.2023

WILEY

HOBOKEN

2198-3844

Advanced Science

10

31

Spojené státy americké

11

https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473