Detail publikačního výsledku

INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION

EZATI, M.; SAADATI, A.; CAO, H.; ZUMBERG, I.; ČMIEL, V.; LUKAS, R.

Originální název

INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION

Anglický název

INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.

Anglický abstrakt

Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.

Klíčová slova

Human prostate cancer cell (PC3), exosomes, fibroblast proliferation and migration

Klíčová slova v angličtině

Human prostate cancer cell (PC3), exosomes, fibroblast proliferation and migration

Autoři

EZATI, M.; SAADATI, A.; CAO, H.; ZUMBERG, I.; ČMIEL, V.; LUKAS, R.

Rok RIV

2025

Vydáno

13.12.2023

Nakladatel

TANGER Ltd.

Místo

Ostrava, Czech Republic

ISBN

978-80-88365-15-0

Kniha

CONFERENCE PROCEEDINGS - NANOCON 2023

Edice

1

ISSN

2694-930X

Periodikum

Proceedings 12th International Conference on Nanomaterials - Research & Application

Stát

Česká republika

Strany od

268

Strany do

272

Strany počet

5

URL

https://doi.org/10.37904/nanocon.2023.4802

Plný text v Digitální knihovně

http://hdl.handle.net/

BibTex

@inproceedings{BUT185088,
  author="Masoumeh {Ezati} and Arezoo {Saadati} and Hoang-Anh {Cao} and Inna {Zumberg} and Vratislav {Čmiel} and Richtera {Lukas}",
  title="INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION",
  booktitle="CONFERENCE PROCEEDINGS - NANOCON 2023",
  year="2023",
  series="1",
  journal="Proceedings 12th International Conference on Nanomaterials - Research & Application",
  pages="268--272",
  publisher="TANGER Ltd.",
  address="Ostrava, Czech Republic",
  doi="10.37904/nanocon.2023.4802",
  isbn="978-80-88365-15-0",
  issn="2694-930X",
  url="https://doi.org/10.37904/nanocon.2023.4802"
}

Dokumenty

nanocon2023_ezati_nanocon