Detail publikačního výsledku

Exploring the potential of 4D bioprinting of smart PLGA-PEG-PLGA based hydrogel for personalized medicine

LYSÁKOVÁ, K.; SAHUĽ, M.; FINNE-WISTRAND, A.; VOJTOVÁ, L.

Originální název

Exploring the potential of 4D bioprinting of smart PLGA-PEG-PLGA based hydrogel for personalized medicine

Anglický název

Exploring the potential of 4D bioprinting of smart PLGA-PEG-PLGA based hydrogel for personalized medicine

Druh

Abstrakt

Originální abstrakt

The development of smart hydrogels for 4D bioprinting holds tremendous promise in the realms of tissue engineering, pharmaceutical production, and medical implant fabrication. This study focuses on utilizing a bioresorbable temperature-responsive hydrogel to create a scaffold capable of responding to external stimuli. The proposed hydrogel material, based on a synthetic biodegradable copolymer known as poly(lactic acid), poly(glycolic acid), and poly(ethylene glycol) (PLGA-PEG-PLGA), enhanced with itaconic acid, offers unparalleled properties for 4D bioprinting. These hydrogels exhibit responsiveness to various physical and chemical stimuli, including blue light, temperature, pH changes, and multivalent ions, rendering them highly suitable for tissue regeneration applications. The combination of low-temperature 3D printing and the designed hydrogel material has the potential to employed avoiding damage to human dermal fibroblasts (HDF) cells and manufacture personalized implants and drug delivery systems.

Anglický abstrakt

The development of smart hydrogels for 4D bioprinting holds tremendous promise in the realms of tissue engineering, pharmaceutical production, and medical implant fabrication. This study focuses on utilizing a bioresorbable temperature-responsive hydrogel to create a scaffold capable of responding to external stimuli. The proposed hydrogel material, based on a synthetic biodegradable copolymer known as poly(lactic acid), poly(glycolic acid), and poly(ethylene glycol) (PLGA-PEG-PLGA), enhanced with itaconic acid, offers unparalleled properties for 4D bioprinting. These hydrogels exhibit responsiveness to various physical and chemical stimuli, including blue light, temperature, pH changes, and multivalent ions, rendering them highly suitable for tissue regeneration applications. The combination of low-temperature 3D printing and the designed hydrogel material has the potential to employed avoiding damage to human dermal fibroblasts (HDF) cells and manufacture personalized implants and drug delivery systems.

Klíčová slova

4D bioprinting, PLGA-PEG-PLGA, human dermal fibroblast cells

Klíčová slova v angličtině

4D bioprinting, PLGA-PEG-PLGA, human dermal fibroblast cells

Autoři

LYSÁKOVÁ, K.; SAHUĽ, M.; FINNE-WISTRAND, A.; VOJTOVÁ, L.

Vydáno

04.09.2023

Nakladatel

Materials Research Society of Serbia

Místo

Belgrade

ISBN

978-86-919111-8-8

Kniha

THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023 Program and Book of Abstracts

Strany od

175

Strany do

175

Strany počet

183

URL

https://mrs-serbia.org.rs/index.php/book-of-abstracts-2023

BibTex

@misc{BUT184951,
  author="Klára {Tušlová} and Martin {Sahuľ} and Anna {Finne-Wistrand} and Lucy {Vojtová}",
  title="Exploring the potential of 4D bioprinting of smart PLGA-PEG-PLGA based hydrogel for personalized medicine",
  booktitle="THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023
Program and Book of Abstracts",
  year="2023",
  pages="175--175",
  publisher="Materials Research Society of Serbia",
  address="Belgrade",
  isbn="978-86-919111-8-8",
  url="https://mrs-serbia.org.rs/index.php/book-of-abstracts-2023",
  note="Abstract"
}