Detail publikačního výsledku

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; SZABOVÁ, J.; LÍZAL, F.

Originální název

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

Anglický název

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.

Anglický abstrakt

Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.

Klíčová slova

Aerosol, particle size, nebulizuer, flow rate, liposom

Klíčová slova v angličtině

Aerosol, particle size, nebulizuer, flow rate, liposom

Autoři

MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; SZABOVÁ, J.; LÍZAL, F.

Rok RIV

2023

Vydáno

29.11.2022

Nakladatel

EDP Sciences

Místo

Dvůr Králové nad Labem

Kniha

Proceedings of the International Conference Experimental Fluid Mechanics 2022

ISSN

2101-6275

Periodikum

EPJ web of conferences (Print)

Stát

Francouzská republika

Strany počet

4

URL

https://www.epj-conferences.org/articles/epjconf/abs/2024/09/epjconf_efm2024_01029/epjconf_efm2024_01029.html

BibTex

@inproceedings{BUT180626,
  author="Ondrej {Mišík} and Milan {Malý} and Ondřej {Cejpek} and Jana {Szabová} and František {Lízal}",
  title="Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer",
  booktitle="Proceedings of the International Conference Experimental Fluid Mechanics 2022",
  year="2022",
  journal="EPJ web of conferences (Print)",
  pages="4",
  publisher="EDP Sciences",
  address="Dvůr Králové nad Labem",
  doi="10.1051/epjconf/202429901029",
  issn="2101-6275",
  url="https://www.epj-conferences.org/articles/epjconf/abs/2024/09/epjconf_efm2024_01029/epjconf_efm2024_01029.html"
}