Detail publikace

Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors

MISSEY, F. DONAHUE, M. WEBER, P. NGOM, I. ACERBO, E. BOTZANOWSKI, B. MIGLIACCIO, L. JIRSA, V. GLOWACKI, E. WILLIAMSON, A.

Originální název

Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Deep brain stimulation (DBS) is a technique commonly used both in clinical and fundamental neurosciences. Classically, brain stimulation requires an implanted and wired electrode system to deliver stimulation directly to the target area. Although techniques such as temporal interference (TI) can provide stimulation at depth without involving any implanted electrodes, these methods still rely on a wired apparatus which limits free movement. Herein organic photocapacitors as untethered light-driven electrodes which convert deep-red light into electric current are reported. Pairs of these ultrathin devices can be driven using lasers at two different frequencies to deliver stimulation at depth via temporally interfering fields. This concept of laser TI stimulation using numerical modeling, tests with phantom brain samples, and finally in vivo tests is validated. Wireless organic photocapacitors are placed on the cortex and elicit stimulation in the hippocampus, while not delivering off-target stimulation in the cortex. This laser-driven wireless TI evokes a neuronal response at depth that is comparable to control experiments induced with deep brain stimulation protocols using implanted electrodes. This work shows that a combination of these two techniques-temporal interference and organic electrolytic photocapacitors-provides a reliable way to target brain structures requiring neither deeply implanted electrodes nor tethered stimulator devices. The laser TI protocol demonstrated here addresses two of the most important drawbacks in the field of DBS and thus holds potential to solve many issues in freely moving animal experiments or for clinical chronic therapy application.

Klíčová slova

deep brain stimulation; optoelectronics; organic bioelectronics; organic electrolytic photocapacitors; temporal interference

Autoři

MISSEY, F.; DONAHUE, M.; WEBER, P.; NGOM, I.; ACERBO, E.; BOTZANOWSKI, B.; MIGLIACCIO, L.; JIRSA, V.; GLOWACKI, E.; WILLIAMSON, A.

Vydáno

1. 6. 2022

Nakladatel

WILEY-V C H VERLAG GMBH

Místo

WEINHEIM

ISSN

1616-301X

Periodikum

ADVANCED FUNCTIONAL MATERIALS

Ročník

32

Číslo

33

Stát

Spolková republika Německo

Strany od

2200691-1

Strany do

2200691-8

Strany počet

8

URL