Detail publikačního výsledku

Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds

KADLECOVÁ, Z.; VOJTOVÁ, L.

Originální název

Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds

Anglický název

Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds

Druh

Abstrakt

Originální abstrakt

This work aims to prepare an injectable thermosensitive drug delivery system enriched by biologically active substances to enhance healing. The mucoadhesive matrix was formed by an FDA-approved biocompatible, non-toxic synthetic polymer based on poly(lactide-co-glycolide) and poly(ethylene glycol) (PLGA-PEG-PLGA) copolymer functionalized with itaconic anhydride (ITA) patented by BUT. This polymer system is body thermo-responsive and is suggested for delivering a pro-healing protein – stable fibroblast growth factor-2 (FGF2-STAB® from Enantis L.t.d.), which stimulates re-epithelization and thus promotes overall tissue regeneration.

Anglický abstrakt

This work aims to prepare an injectable thermosensitive drug delivery system enriched by biologically active substances to enhance healing. The mucoadhesive matrix was formed by an FDA-approved biocompatible, non-toxic synthetic polymer based on poly(lactide-co-glycolide) and poly(ethylene glycol) (PLGA-PEG-PLGA) copolymer functionalized with itaconic anhydride (ITA) patented by BUT. This polymer system is body thermo-responsive and is suggested for delivering a pro-healing protein – stable fibroblast growth factor-2 (FGF2-STAB® from Enantis L.t.d.), which stimulates re-epithelization and thus promotes overall tissue regeneration.

Klíčová slova

fibroblast growth factor-2; liposome; encapsulation

Klíčová slova v angličtině

fibroblast growth factor-2; liposome; encapsulation

Autoři

KADLECOVÁ, Z.; VOJTOVÁ, L.

Rok RIV

2022

Vydáno

20.04.2022

Nakladatel

Czech Chemical Society

ISSN

2336-7210

Periodikum

Czech Chemical Society Symposium Series

Svazek

20

Číslo

1

Stát

Česká republika

Strany od

19

Strany do

20

Strany počet

52

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/31/45

BibTex

@misc{BUT177961,
  author="Zuzana {Kadlecová} and Lucy {Vojtová}",
  title="Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds",
  year="2022",
  journal="Czech Chemical Society Symposium Series",
  volume="20",
  number="1",
  pages="19--20",
  publisher="Czech Chemical Society",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/31/45",
  note="Abstract"
}