Detail publikace

Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

EJNEBY, M. JAKEŠOVÁ, M. FERRERO, J. MIGLIACCIO, L. SAHALIANOV, I. ZHAO, Z. BERGGREN, M. KHODAGHOLY, D. DEREK, V. GELINAS, J. GLOWACKI, E.

Originální název

Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm(3) thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-mu s pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves. An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.

Klíčová slova

NEURAL STIMULATION; SAFETY; ELECTRODE; EFFICACY; POWER

Autoři

EJNEBY, M.; JAKEŠOVÁ, M.; FERRERO, J.; MIGLIACCIO, L.; SAHALIANOV, I.; ZHAO, Z.; BERGGREN, M.; KHODAGHOLY, D.; DEREK, V.; GELINAS, J.; GLOWACKI, E.

Vydáno

22. 11. 2021

Nakladatel

Springer Nature

Místo

BERLIN

ISSN

2157-846X

Periodikum

Nature Biomedical Engineering

Ročník

6

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

741

Strany do

753

Strany počet

16

URL

https://www.nature.com/articles/s41551-021-00817-7

Plný text v Digitální knihovně

http://hdl.handle.net/11012/208151

BibTex

@article{BUT176503,
  author="Malin Silverå {Ejneby} and Marie {Jakešová} and Jose J. {Ferrero} and Ludovico {Migliaccio} and Ihor {Sahalianov} and Zifang {Zhao} and Magnus {Berggren} and Dion {Khodagholy} and Vedran {Derek} and Jennifer N. {Gelinas} and Eric Daniel {Glowacki}",
  title="Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor",
  journal="Nature Biomedical Engineering",
  year="2021",
  volume="6",
  number="1",
  pages="741--753",
  doi="10.1038/s41551-021-00817-7",
  issn="2157-846X",
  url="https://www.nature.com/articles/s41551-021-00817-7"
}