Detail publikačního výsledku

Questions about the role of P3HT nanoparticles in retinal stimulation

PALANKER, D.; GLOWACKI, E.; GHEZZI, D.

Originální název

Questions about the role of P3HT nanoparticles in retinal stimulation

Anglický název

Questions about the role of P3HT nanoparticles in retinal stimulation

Druh

Článek WoS

Originální abstrakt

Maya-Vetencourt et al.1 recently reported that poly[3-hexylthiophene] nanoparticles (P3HT NPs) injected in the subretinal space of the rat model of retinal dystrophy (the Royal College of Surgeons (RCS) model)) “mediate light-evoked stimulation of retinal neurons and persistently rescue visual function”. The article also reported that the light-evoked stimulation of retinal neurons is electrical in nature and is mediated by a capacitive coupling between the NPs and the cell membrane. To support these claims, the authors performed a series of experiments that demonstrated the P3HT NPs induced a cellular response in vitro, a retinal response ex vivo and rescue the visual functions in vivo. However, a number of inconsistencies throughout the article cast doubt on these results and their interpretation, as outlined below.

Anglický abstrakt

Maya-Vetencourt et al.1 recently reported that poly[3-hexylthiophene] nanoparticles (P3HT NPs) injected in the subretinal space of the rat model of retinal dystrophy (the Royal College of Surgeons (RCS) model)) “mediate light-evoked stimulation of retinal neurons and persistently rescue visual function”. The article also reported that the light-evoked stimulation of retinal neurons is electrical in nature and is mediated by a capacitive coupling between the NPs and the cell membrane. To support these claims, the authors performed a series of experiments that demonstrated the P3HT NPs induced a cellular response in vitro, a retinal response ex vivo and rescue the visual functions in vivo. However, a number of inconsistencies throughout the article cast doubt on these results and their interpretation, as outlined below.

Klíčová slova

P3HT nanoparticles; retinal stimulation

Klíčová slova v angličtině

P3HT nanoparticles; retinal stimulation

Autoři

PALANKER, D.; GLOWACKI, E.; GHEZZI, D.

Rok RIV

2023

Vydáno

23.12.2021

Nakladatel

NATURE PORTFOLIO

Místo

BERLIN

ISSN

1748-3395

Periodikum

Nature Nanotechnology

Svazek

16

Číslo

12

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1330

Strany do

1332

Strany počet

3

URL

https://www.nature.com/articles/s41565-021-01044-6

BibTex

@article{BUT176436,
  author="Daniel {Palanker} and Eric Daniel {Glowacki} and Diego {Ghezzi}",
  title="Questions about the role of P3HT nanoparticles in retinal stimulation",
  journal="Nature Nanotechnology",
  year="2021",
  volume="16",
  number="12",
  pages="1330--1332",
  doi="10.1038/s41565-021-01044-6",
  issn="1748-3387",
  url="https://www.nature.com/articles/s41565-021-01044-6"
}