Detail publikace

Oxygen Reduction Reactions at Neurostimulation Electrodes

EHLICH, J. MIGLIACCIO, L. NIKIĆ, M. BRODSKÝ, J. GABLECH, I. GLOWACKI, E.

Originální název

Oxygen Reduction Reactions at Neurostimulation Electrodes

Typ

přednáška

Jazyk

angličtina

Originální abstrakt

During electrical neural stimulation, charge-balanced biphasic current pulses are typically used to trigger action potentials in excitable tissues. Cathodic pulses depolarize cells, evoking action potentials, meanwhile subsequent anodic pulses are meant to reverse the products of possible electrochemical processes back to their original form. Balanced biphasic current pulses are thus generally considered to be safe for chronic applications [1]. However recently it has been found, that not all reactions that could possibly happen at the electrode-tissue interface during the stimulation are perfectly reversible. Products of these reactions can be possibly dangerous to the tissue or act as signalling molecules. The identity and the scale of such reactions still remains an unexplored area [2]. Our work examines oxygen reduction reactions at the electrodes made out of commonly used materials used for neural stimulation electrodes. Oxygen can be reduced either to water or hydrogen peroxide by 4- or 2-electron process. Both reactions can significantly reduce the quantity of dissolved oxygen near the electrode, creating hypoxic conditions harmful to neurons. Peroxide, meanwhile, can induce toxic reactions or act as a signalling molecule. We are examining the amount of reduced oxygen and produced peroxide by various biphasic stimulation protocols and comparing electrocatalytic activities of studied materials. Results of this study should help to engineer novel and potentially safer neurostimulation devices and protocols.

Klíčová slova

bioelectronics, neurostimulation, faradaic reactions, hypoxia, reactive oxygen species

Autoři

EHLICH, J.; MIGLIACCIO, L.; NIKIĆ, M.; BRODSKÝ, J.; GABLECH, I.; GLOWACKI, E.

Vydáno

4. 11. 2021

Nakladatel

CROATIAN NEUROELECTRONICS SYMPOSIUM / ZAGREB BIOELECTRONICS WORKSHOP 2021

Místo

Zagreb, Croatia

Strany počet

1

URL

BibTex

@misc{BUT173135,
  author="Jiří {Ehlich} and Ludovico {Migliaccio} and Marta {Nikić} and Jan {Brodský} and Imrich {Gablech} and Eric Daniel {Glowacki}",
  title="Oxygen Reduction Reactions at Neurostimulation Electrodes",
  year="2021",
  pages="1",
  publisher="CROATIAN NEUROELECTRONICS SYMPOSIUM / ZAGREB BIOELECTRONICS WORKSHOP 2021",
  address="Zagreb, Croatia",
  url="https://www.croneuro.com/program/",
  note="lecture"
}