Detail publikačního výsledku

Preparation and characterisation of functionalized wound dressings

DZURICKÁ, L.; BENDOVÁ, A.; HOOVÁ, J.; MATOUŠKOVÁ, P.; MÁROVÁ, I.

Originální název

Preparation and characterisation of functionalized wound dressings

Anglický název

Preparation and characterisation of functionalized wound dressings

Druh

Abstrakt

Originální abstrakt

This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber dressings were constituted from poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers were assembled by electrospinning and force spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also evaluated. the results showed good antimicrobial efficacy of functionalized materials.

Anglický abstrakt

This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber dressings were constituted from poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers were assembled by electrospinning and force spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also evaluated. the results showed good antimicrobial efficacy of functionalized materials.

Klíčová slova

wound dressings, ampicillin, poly(3‑hydroxybutyrate), chitosan, alginate, antimicrobial activity, cytotoxicity

Klíčová slova v angličtině

wound dressings, ampicillin, poly(3‑hydroxybutyrate), chitosan, alginate, antimicrobial activity, cytotoxicity

Autoři

DZURICKÁ, L.; BENDOVÁ, A.; HOOVÁ, J.; MATOUŠKOVÁ, P.; MÁROVÁ, I.

Rok RIV

2021

Vydáno

26.11.2020

Nakladatel

Vysoké učení technické v Brně, Fakulta chemická

Místo

Brno

ISBN

978-80-214-5920-0

Kniha

Studentská odborná konference CHEMIE JE ŽIVOT 2020 Sborník abstraktů

Strany od

59

Strany do

60

Strany počet

164

URL

https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641

BibTex

@misc{BUT166180,
  author="Lucia {Dzurická} and Agáta {Bendová} and Julie {Hoová} and Petra {Skoumalová} and Ivana {Márová}",
  title="Preparation and characterisation of functionalized wound dressings",
  booktitle="Studentská odborná konference CHEMIE JE ŽIVOT 2020 Sborník abstraktů",
  year="2020",
  edition="první",
  pages="59--60",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Brno",
  isbn="978-80-214-5920-0",
  url="https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641",
  note="Abstract"
}