Detail publikace

In vitro bioactivity of silicon nitride-hydroxyapatite composites

Precnerova, M Bodigova, K Frajkorova, F Galuskova, D Novakova, ZV Vojtassak, J Lences, Z Sajgalik, P

Originální název

In vitro bioactivity of silicon nitride-hydroxyapatite composites

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Silicon nitride-based ceramics are characterised especially by high chemical resistance, superior combination of fracture toughness, hardness and bioinertness. However, the biological applications often require additional properties, e.g. bioactivity enabling stronger bonding to the host tissue. Hydroxyapatite coating prepared by sol gel route, which provides pure, stable and nano-crystalline product is one of the ways to achieve bioactivity of bioinert ceramics. Therefore silicon nitride hydroxyapatite composites were prepared by infiltration of hydroxyapatite precursor sol into the silicon nitride based porous ceramics. The conditions of sol preparation were optimised to be appropriate for pure HA synthesis: ageing at elevated temperature (85 degrees C) and calcinations at 500 degrees C for 1 h. Cytotoxicity and in vitro bioactivity of Si3N4-HA composites were tested in order to verify the effect of hydroxyapatite addition on the biological properties of composite. After immersion of porous composite into simulated body fluid (SBF) for 21 days, calcium phosphate layer was formed on the surface of silicon nitride hydroxyapatite composites, indicating their bioactivity. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Klíčová slova

Si3N4; Apatite; Biomedical applications; Bioactivity

Autoři

Precnerova, M; Bodigova, K; Frajkorova, F; Galuskova, D; Novakova, ZV; Vojtassak, J; Lences, Z; Sajgalik, P

Vydáno

1. 7. 2015

Nakladatel

ELSEVIER SCI LTD

Místo

OXFORD

ISSN

1873-3956

Periodikum

CERAMICS INTERNATIONAL

Ročník

41

Číslo

6

Stát

Spojené království Velké Británie a Severního Irska

Strany od

8100

Strany do

8108

Strany počet

9

URL

http://apps.webofknowledge.com.ezproxy.lib.vutbr.cz/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=E6JXvEJHJpsw8EibggE&page=1&doc=1

BibTex

@article{BUT163563,
  author="Precnerova, M and Bodigova, K and Frajkorova, F and Galuskova, D and Novakova, ZV and Vojtassak, J and Lences, Z and Sajgalik, P",
  title="In vitro bioactivity of silicon nitride-hydroxyapatite composites",
  journal="CERAMICS INTERNATIONAL",
  year="2015",
  volume="41",
  number="6",
  pages="8100--8108",
  doi="10.1016/j.ceramint.2015.03.011",
  issn="1873-3956",
  url="http://apps.webofknowledge.com.ezproxy.lib.vutbr.cz/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=E6JXvEJHJpsw8EibggE&page=1&doc=1"
}