Detail publikačního výsledku

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode

DUROVIC, A.; STOJANOVIC, Z.; KRAVIC, S.; KOS, J.; RICHTERA, L.

Originální název

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode

Anglický název

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode

Druh

Článek WoS

Originální abstrakt

A sensitive square-wave voltammetry method was developed to determine cholecalciferol (vitamin D-3) in pharmaceutical products at boron-doped diamond electrode as a working electrode. Vitamin D-3 provided a well-defined voltammetric peak at around +1.00 V (vs. Ag/AgCl, 3.5 mol dm(-3)) in 0.02 mol dm(-3) Britton-Robinson buffer pH 5.0 prepared in 50 % ethanol. The influence of various factors such as type and pH of the supporting electrolyte, scan rate and square-wave parameters were studied and optimized. Under optimum conditions, the oxidation peak current increased linearly with the concentration of vitamin D-3 over the range of 2 to 200 mu mol dm(-3). The calculated limit of detection and limit of quantitation were 0.17 mu mol dm(-3) and 0.51 mu mol dm(-3), respectively. The boron-doped diamond electrode exhibited specific recognition capability for cholecalciferol amongst possible interferences, and the determination of vitamin D-3 was possible in samples such as commercial pharmaceutical products without complicated sample pretreatments.

Anglický abstrakt

A sensitive square-wave voltammetry method was developed to determine cholecalciferol (vitamin D-3) in pharmaceutical products at boron-doped diamond electrode as a working electrode. Vitamin D-3 provided a well-defined voltammetric peak at around +1.00 V (vs. Ag/AgCl, 3.5 mol dm(-3)) in 0.02 mol dm(-3) Britton-Robinson buffer pH 5.0 prepared in 50 % ethanol. The influence of various factors such as type and pH of the supporting electrolyte, scan rate and square-wave parameters were studied and optimized. Under optimum conditions, the oxidation peak current increased linearly with the concentration of vitamin D-3 over the range of 2 to 200 mu mol dm(-3). The calculated limit of detection and limit of quantitation were 0.17 mu mol dm(-3) and 0.51 mu mol dm(-3), respectively. The boron-doped diamond electrode exhibited specific recognition capability for cholecalciferol amongst possible interferences, and the determination of vitamin D-3 was possible in samples such as commercial pharmaceutical products without complicated sample pretreatments.

Klíčová slova

Boron doped diamond electrode; Pharmaceutical samples; Sensors; Vitamin D; Voltammetry

Klíčová slova v angličtině

Boron doped diamond electrode; Pharmaceutical samples; Sensors; Vitamin D; Voltammetry

Autoři

DUROVIC, A.; STOJANOVIC, Z.; KRAVIC, S.; KOS, J.; RICHTERA, L.

Rok RIV

2021

Vydáno

30.04.2020

ISSN

1040-0397

Periodikum

ELECTROANALYSIS

Svazek

32

Číslo

4

Stát

Spolková republika Německo

Strany od

741

Strany do

748

Strany počet

8

URL

https://onlinelibrary.wiley.com/doi/abs/10.1002/elan.201900532

BibTex

@article{BUT161351,
  author="Ana {Durovic} and Zorica {Stojanovic} and Snezana {Kravic} and Jovana {Kos} and Lukáš {Richtera}",
  title="Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode",
  journal="ELECTROANALYSIS",
  year="2020",
  volume="32",
  number="4",
  pages="741--748",
  doi="10.1002/elan.201900532",
  issn="1040-0397",
  url="https://onlinelibrary.wiley.com/doi/abs/10.1002/elan.201900532"
}

Dokumenty

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode