Detail publikačního výsledku

Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

MANZANARES-PALENZUELA, C.; POURRAHIMI, A.; GONZALEZ, J.; SOFER, Z.; PYKAL, M.; OTYEPKA, M.; PUMERA, M.

Originální název

Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

Anglický název

Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations

Druh

Článek WoS

Originální abstrakt

The integration of nucleic acids with nanomaterials has attracted great attention from various research communities in search of new nanoscale tools for a range of applications, from electronics to biomedical uses. MXenes are a new class of multielement 2D materials baring exciting properties mostly directed to energy-related fields. These advanced materials are now beginning to enter the biomedical field given their biocompatibility, hydrophilicity and near-infrared absorption. Herein, we elucidate the interaction of MXene Ti3C2Tx with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.

Anglický abstrakt

The integration of nucleic acids with nanomaterials has attracted great attention from various research communities in search of new nanoscale tools for a range of applications, from electronics to biomedical uses. MXenes are a new class of multielement 2D materials baring exciting properties mostly directed to energy-related fields. These advanced materials are now beginning to enter the biomedical field given their biocompatibility, hydrophilicity and near-infrared absorption. Herein, we elucidate the interaction of MXene Ti3C2Tx with fluorophore-tagged DNA by fluorescence measurements and molecular dynamics simulations. The system showed potential for biosensing with unequivocal detection at picomole levels and single-base discrimination. We found that this material possesses a kinetically unique entrapment/release behavior, with potential implications in time-controlled biomolecule delivery. Our findings present MXenes as platforms for binding nucleic acids, contributing to their potential for hybridization-based biosensing and related bio-applications.

Klíčová slova

2-DIMENSIONAL TITANIUM CARBIDE; GRAPHENE; NANOSHEETS; PLATFORM; TI3C2; OLIGONUCLEOTIDES; NANOPARTICLES; ADSORPTION; COMPOSITE; SIRNA

Klíčová slova v angličtině

2-DIMENSIONAL TITANIUM CARBIDE; GRAPHENE; NANOSHEETS; PLATFORM; TI3C2; OLIGONUCLEOTIDES; NANOPARTICLES; ADSORPTION; COMPOSITE; SIRNA

Autoři

MANZANARES-PALENZUELA, C.; POURRAHIMI, A.; GONZALEZ, J.; SOFER, Z.; PYKAL, M.; OTYEPKA, M.; PUMERA, M.

Rok RIV

2020

Vydáno

21.11.2019

ISSN

2041-6520

Periodikum

Chemical Science

Svazek

10

Číslo

43

Stát

Spojené království Velké Británie a Severního Irska

Strany od

10010

Strany do

10017

Strany počet

8

URL

https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc03049b#!divAbstract

BibTex

@article{BUT160066,
  author="Carmen Lorena {Manzanares-Palenzuela} and Amir Masoud {Pourrahimi} and Jesus {Gonzalez} and Zdeněk {Sofer} and Martin {Pykal} and Michal {Otyepka} and Martin {Pumera}",
  title="Interaction of single- and double-stranded DNA with multilayer MXene by fluorescence spectroscopy and molecular dynamics simulations",
  journal="Chemical Science",
  year="2019",
  volume="10",
  number="43",
  pages="10010--10017",
  doi="10.1039/c9sc03049b",
  issn="2041-6520",
  url="https://pubs.rsc.org/en/content/articlelanding/2019/sc/c9sc03049b#!divAbstract"
}