Detail publikačního výsledku

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

OLEJNÍČKOVÁ, V.; JANOUŠEK, O.; RONZHINA, M.; HEJČ, J.; KVASILOVA, A.; ZABRODSKA, E.; SEDMERA, D.

Originální název

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

Anglický název

Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of AV junction (AVJ) during prenatal development. However, technical limitations have challenge to study foetal heart electrophysiology and are hampering the understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of rethrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during whole prenatal periods. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of AV electrical continuity was still detected in post-septated foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none APs were detected in prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling and spatiotemporally localise electrically active APs in the critical growing eriods.

Anglický abstrakt

Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of AV junction (AVJ) during prenatal development. However, technical limitations have challenge to study foetal heart electrophysiology and are hampering the understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of rethrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during whole prenatal periods. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of AV electrical continuity was still detected in post-septated foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none APs were detected in prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling and spatiotemporally localise electrically active APs in the critical growing eriods.

Klíčová slova

Optical mapping, action potential, di-4-ANEPPS, AV junction remodelling, foetal avian heart

Klíčová slova v angličtině

Optical mapping, action potential, di-4-ANEPPS, AV junction remodelling, foetal avian heart

Autoři

OLEJNÍČKOVÁ, V.; JANOUŠEK, O.; RONZHINA, M.; HEJČ, J.; KVASILOVA, A.; ZABRODSKA, E.; SEDMERA, D.

Rok RIV

2019

Vydáno

26.09.2018

Místo

Maastricht

Kniha

Computing in Cardiology 2018

ISSN

2325-887X

Periodikum

Computing in Cardiology

Svazek

45

Číslo

1

Stát

Spojené státy americké

Strany od

1

Strany do

4

Strany počet

4

URL

https://ieeexplore.ieee.org/document/8744067

BibTex

@inproceedings{BUT151034,
  author="OLEJNÍČKOVÁ, V. and JANOUŠEK, O. and RONZHINA, M. and HEJČ, J. and KVASILOVA, A. and ZABRODSKA, E. and SEDMERA, D.",
  title="Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart",
  booktitle="Computing in Cardiology 2018",
  year="2018",
  journal="Computing in Cardiology",
  volume="45",
  number="1",
  pages="1--4",
  address="Maastricht",
  doi="10.22489/CinC.2018.055",
  url="https://ieeexplore.ieee.org/document/8744067"
}