Detail publikačního výsledku

Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility

BUCHTELOVÁ, H.; STRMISKA, V.; DOSTÁLOVÁ, S.; MICHÁLEK, P.; KŘÍŽKOVÁ, S.; KOPEL, P.; HYNEK, D.; RICHTERA, L.; ADAM, V.; HEGER, Z.

Originální název

Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility

Anglický název

Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

The current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The resulting RuNPs were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The cytotoxic effects of the complex were tested using cell lines representing breast and ovarian cancers and neuroblastoma. Although bare RuNPs had only negligible cytotoxicity, RuPDox caused an enhancement of doxorubicin cytotoxicity when compared to free doxorubicin. RuPDox promoted significantly increased stability of doxorubicin in human plasma and pronounced hemocompatibility assayed on human red blood cells. Results demonstrate that biocompatible RuNPs could have a great potential as versatile nanoplatform to enhance efficiency of anticancer therapy.

Anglický abstrakt

The current study demonstrates design preparation and characterization of biocompatible hybrid ruthenium core-shell nanoparticles (RuNPs) coated with polyvinylpyrrolidone (PVP) and polyoxyethylene stearate (POES). The resulting RuNPs were loaded with doxorubicin, as model anticancer drug. Resulting complex has an exceptional stability in physiological conditions. The cytotoxic effects of the complex were tested using cell lines representing breast and ovarian cancers and neuroblastoma. Although bare RuNPs had only negligible cytotoxicity, RuPDox caused an enhancement of doxorubicin cytotoxicity when compared to free doxorubicin. RuPDox promoted significantly increased stability of doxorubicin in human plasma and pronounced hemocompatibility assayed on human red blood cells. Results demonstrate that biocompatible RuNPs could have a great potential as versatile nanoplatform to enhance efficiency of anticancer therapy.

Klíčová slova

Biocompatibility; nanomedicine; polyvinylpyrrolidone; polyoxyethylene stearate

Klíčová slova v angličtině

Biocompatibility; nanomedicine; polyvinylpyrrolidone; polyoxyethylene stearate

Autoři

BUCHTELOVÁ, H.; STRMISKA, V.; DOSTÁLOVÁ, S.; MICHÁLEK, P.; KŘÍŽKOVÁ, S.; KOPEL, P.; HYNEK, D.; RICHTERA, L.; ADAM, V.; HEGER, Z.

Rok RIV

2019

Vydáno

31.12.2017

Nakladatel

Mendel University in Brno

ISBN

978-80-7509-529-9

Kniha

MendelNet 2017

Strany od

837

Strany do

842

Strany počet

6

URL

https://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4

Plný text v Digitální knihovně

http://hdl.handle.net/11012/84172

BibTex

@inproceedings{BUT148707,
  author="Hana {Michálková} and Vladislav {Strmiska} and Simona {Dostálová} and Petr {Michálek} and Soňa {Křížková} and Pavel {Kopel} and David {Hynek} and Lukáš {Richtera} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility",
  booktitle="MendelNet 2017",
  year="2017",
  pages="837--842",
  publisher="Mendel University in Brno",
  isbn="978-80-7509-529-9",
  url="https://mendelnet.cz/artkey/mnt-201701-0092_Ruthenium-based-core-shell-nanoparticles-with-exceptional-in-vitro-biocompatibility.php?back=/magno/mnt/2017/mn1.php?secid=4"
}

Dokumenty

Ruthenium-based core-shell nanoparticles with exceptional in vitro biocompatibility
MendelNet_mnt-201701-0092