Detail publikačního výsledku

Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications

PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; PAVLIŇÁK, D.; KHUNOVÁ, V.; VOJTOVÁ, L.

Originální název

Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications

Anglický název

Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications

Druh

Článek WoS

Originální abstrakt

Nanofibrous elastic material based on the blend of hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic gelatin (Gel) reinforced with halloysite nanotubes (HNTs) was prepared by electrospinning process by respecting principles of "green chemistry" required for tissue engineering and drug delivery carriers. Three different kinds of HNTs with similar aspect ratio, but different length and inner diameter were examined to explain the effect of HNT concentration and geometry on a structure, morphology, chemical composition, mechanical properties and biocompatibility of nanostructured materials. Reinforcing effect of each type of HNTs has been confirmed up to 6 wt%. However, the highest improvement of mechanical properties was exhibited by addition just 0.5 wt% of HNTs. All HNT modified nanofibers have been confirmed as non-cytotoxic based on the interaction with mouse fibroblasts NIH-3T3 cells and therefore suitable for biomedical applications, e.g. as wound healing coverings with controlled drug delivery.

Anglický abstrakt

Nanofibrous elastic material based on the blend of hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic gelatin (Gel) reinforced with halloysite nanotubes (HNTs) was prepared by electrospinning process by respecting principles of "green chemistry" required for tissue engineering and drug delivery carriers. Three different kinds of HNTs with similar aspect ratio, but different length and inner diameter were examined to explain the effect of HNT concentration and geometry on a structure, morphology, chemical composition, mechanical properties and biocompatibility of nanostructured materials. Reinforcing effect of each type of HNTs has been confirmed up to 6 wt%. However, the highest improvement of mechanical properties was exhibited by addition just 0.5 wt% of HNTs. All HNT modified nanofibers have been confirmed as non-cytotoxic based on the interaction with mouse fibroblasts NIH-3T3 cells and therefore suitable for biomedical applications, e.g. as wound healing coverings with controlled drug delivery.

Klíčová slova

Electrospinning; Halloysite nanotubes; Nanofibers; Biocompatibility; Polymer nanocomposit

Klíčová slova v angličtině

Electrospinning; Halloysite nanotubes; Nanofibers; Biocompatibility; Polymer nanocomposit

Autoři

PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; PAVLIŇÁK, D.; KHUNOVÁ, V.; VOJTOVÁ, L.

Rok RIV

2019

Vydáno

01.10.2018

ISSN

0928-4931

Periodikum

Materials Science & Engineering C-Materials for Biological Applications

Svazek

91

Číslo

1

Stát

Nizozemsko

Strany od

94

Strany do

102

Strany počet

9

URL

https://www.sciencedirect.com/science/article/pii/S0928493117333313

BibTex

@article{BUT148625,
  author="Veronika {Pavliňáková} and Zdenka {Fohlerová} and David {Pavliňák} and Viera {Khunová} and Lucy {Vojtová}",
  title="Effect of halloysite nanotube structure on physical, chemical, structural and biological properties of elastic polycaprolactone/gelatin nanofibers for wound healing applications",
  journal="Materials Science & Engineering C-Materials for Biological Applications",
  year="2018",
  volume="91",
  number="1",
  pages="94--102",
  doi="10.1016/j.msec.2018.05.033",
  issn="0928-4931",
  url="https://www.sciencedirect.com/science/article/pii/S0928493117333313"
}