Detail publikačního výsledku

Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin

MOULICK, A.; MILOSAVLJEVIĆ, V.; NGUYEN, H.; KOPEL, P.; ADAM, V.

Originální název

Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin

Anglický název

Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin

Druh

Článek WoS

Originální abstrakt

It has been suggested that multiwalled carbon nanotubes (MWCNTs) interacting with pharmaceutics may be introduced into the body as nanocarriers. To deliver the anticancer drugs, covalent or noncovalent functionalization of MWCNTs is required. In this study, the influence of oxidation on MWCNTs in the interaction with chemotherapeutic drug, doxorubicin, was characterized. The binding of doxorubicin with MWCNTs decreased rapidly with the increasing oxidation period with sulfuric acid. However, with nitric acid, the interaction increased initially and slowly decreased with time. The best results were obtained for sulfuric and nitric acid following 1 and 3h of oxidation, respectively. The results show that sulfuric acid provided more favorable interaction for MWCNTs with doxorubicin than nitric acid.

Anglický abstrakt

It has been suggested that multiwalled carbon nanotubes (MWCNTs) interacting with pharmaceutics may be introduced into the body as nanocarriers. To deliver the anticancer drugs, covalent or noncovalent functionalization of MWCNTs is required. In this study, the influence of oxidation on MWCNTs in the interaction with chemotherapeutic drug, doxorubicin, was characterized. The binding of doxorubicin with MWCNTs decreased rapidly with the increasing oxidation period with sulfuric acid. However, with nitric acid, the interaction increased initially and slowly decreased with time. The best results were obtained for sulfuric and nitric acid following 1 and 3h of oxidation, respectively. The results show that sulfuric acid provided more favorable interaction for MWCNTs with doxorubicin than nitric acid.

Klíčová slova

Carbon nanotubes (CNTs); differential pulse voltammetry (DPV); glassy carbon electrode (GCE); multiwalled carbon nanotubes (MWCNTs); single-walled carbon nanotubes (SWCNTs)

Klíčová slova v angličtině

Carbon nanotubes (CNTs); differential pulse voltammetry (DPV); glassy carbon electrode (GCE); multiwalled carbon nanotubes (MWCNTs); single-walled carbon nanotubes (SWCNTs)

Autoři

MOULICK, A.; MILOSAVLJEVIĆ, V.; NGUYEN, H.; KOPEL, P.; ADAM, V.

Rok RIV

2018

Vydáno

01.11.2017

ISSN

0003-2719

Periodikum

ANALYTICAL LETTERS

Svazek

50

Číslo

14

Stát

Spojené státy americké

Strany od

2335

Strany do

2341

Strany počet

7

BibTex

@article{BUT141269,
  author="Amitava {Moulick} and Vedran {Milosavljević} and Hoai Viet {Nguyen} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Electrochemical characterization of the interaction of multiwalled carbon nanotubes with doxorubicin",
  journal="ANALYTICAL LETTERS",
  year="2017",
  volume="50",
  number="14",
  pages="2335--2341",
  doi="10.1080/00032719.2017.1284860",
  issn="0003-2719"
}