Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart

Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart

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Aim: High frequency content of QRS complex (HF-QRS) is thought to be related to local conduction velocity (CV). There also exists the evidence suggesting the coupling between CV and mechanical stretch via so-called mechano-electric feedback. The aim of this study was to investigate possible relationship between left ventricular (LV) load and the most common HF-QRS parameters. Methods: Six isolated rabbit hearts in working mode underwent an experimental protocol consisting of upward and downward steps in preload (8-11 cmH2O). Eight unipolar pseudo-ECGs, left atrial pressure, and flow rate were recorded at fs=10 kHz and 16-bit resolution. QRS complexes from hemodynamically stable experiment phase were clustered, aligned, and decomposed into 3 HF-QRS bands followed by the assessment of power envelope RMS, the tallest peak value and its position. Results: No statistically significant changes associated with LV load alteration were observed in HF-QRS parameter. Conclusion: No evidence of load dependent changes in conduction velocity was found in the study. However, HF signal may represent a complex spatial depolarization behavior. Low sensitivity of used metrics should also be taken into consideration.

Aim: High frequency content of QRS complex (HF-QRS) is thought to be related to local conduction velocity (CV). There also exists the evidence suggesting the coupling between CV and mechanical stretch via so-called mechano-electric feedback. The aim of this study was to investigate possible relationship between left ventricular (LV) load and the most common HF-QRS parameters. Methods: Six isolated rabbit hearts in working mode underwent an experimental protocol consisting of upward and downward steps in preload (8-11 cmH2O). Eight unipolar pseudo-ECGs, left atrial pressure, and flow rate were recorded at fs=10 kHz and 16-bit resolution. QRS complexes from hemodynamically stable experiment phase were clustered, aligned, and decomposed into 3 HF-QRS bands followed by the assessment of power envelope RMS, the tallest peak value and its position. Results: No statistically significant changes associated with LV load alteration were observed in HF-QRS parameter. Conclusion: No evidence of load dependent changes in conduction velocity was found in the study. However, HF signal may represent a complex spatial depolarization behavior. Low sensitivity of used metrics should also be taken into consideration.

ventricular repolarization, ventricular load, preload, high-frequency analysis, mechano-electric coupling, dynamic response, isolated heart, working heart

ventricular repolarization, ventricular load, preload, high-frequency analysis, mechano-electric coupling, dynamic response, isolated heart, working heart

NOVOTNÁ, P.; HEJČ, J.; RONZHINA, M.; JANOUŠEK, O.; STRAČINA, T.; OLEJNÍČKOVÁ, V.; NOVÁKOVÁ, M.; KOLÁŘOVÁ, J.

2018

30.09.2017

Computing in Cardiology 2017

Rennes, France

978-1-5090-0684-7

Computing in Cardiology 2017

44

0276-6574

Computers in Cardiology

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