software

FireProt is a web server for an automated design of thermostable mutants. The design of thermostable mutants is based on integration of structural and evolutionary infromation obtained from several bioinfromatics databases and computational tools. FireProt strategy combines energy and evolution based approaches together with several filters that accelerate the calculation by omitting potentially deleterious mutations. Within its workflow, FireProt integrates 16 computational tools, utilizing both sequence and structural information in the process. FIreProt web server provides users with a one-stop-shop solution for the design of thermostable proteins, constructed by three distinct strategies. Futhermore, the server allows users to include user-defined mutations into the constructed thermostable protein and generate corresponding sequences in the FASTA format.

protein engineering, thermostable proteins, multiple-point mutants, protein stability

29. 12. 2016

Nástroj je dostupný na internetové adrese: http://loschmidt.chemi.muni.cz/fireprot

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