Detail publikačního výsledku

Cell type specificity of neurovascular coupling in cerebral cortex

UHLÍŘOVÁ, H.; KILIÇ, K.; TIAN, P.; THUNEMANN, M.; DESJARDINS, M.; SAISAN, P.; SAKADŽIC, S.; NESS, T.; MATEO, C.; CHENG, Q.; WELDY, K.; RAZOUX, F.; VANDENBERGHE, M.; CREMONESI, J.; FERRI, C.; NIZAR, K.; SRIDHAR, V.; STEED, T.; ABASHIN, M.; FAINMAN, Y.; MASLIAH, E.; DJUROVIC, S.; ANDREASSEN, O.; SILVA, G.; BOAS, D.; KLEINFELD, D.; BUXTON, R.; EINEVOLL, G.; DALE, A.; DEVOR, A.

Originální název

Cell type specificity of neurovascular coupling in cerebral cortex

Anglický název

Cell type specificity of neurovascular coupling in cerebral cortex

Druh

Článek WoS

Originální abstrakt

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

Anglický abstrakt

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

Klíčová slova

cerebrovascular regulation, 2-photon imaging

Klíčová slova v angličtině

cerebrovascular regulation, 2-photon imaging

Autoři

UHLÍŘOVÁ, H.; KILIÇ, K.; TIAN, P.; THUNEMANN, M.; DESJARDINS, M.; SAISAN, P.; SAKADŽIC, S.; NESS, T.; MATEO, C.; CHENG, Q.; WELDY, K.; RAZOUX, F.; VANDENBERGHE, M.; CREMONESI, J.; FERRI, C.; NIZAR, K.; SRIDHAR, V.; STEED, T.; ABASHIN, M.; FAINMAN, Y.; MASLIAH, E.; DJUROVIC, S.; ANDREASSEN, O.; SILVA, G.; BOAS, D.; KLEINFELD, D.; BUXTON, R.; EINEVOLL, G.; DALE, A.; DEVOR, A.

Rok RIV

2017

Vydáno

31.05.2016

Nakladatel

eLife Sciences Publications

ISSN

2050-084X

Periodikum

eLife

Svazek

5

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

23

Strany počet

23

URL

https://elifesciences.org/content/5/e14315

Plný text v Digitální knihovně

http://hdl.handle.net/11012/204286

BibTex

@article{BUT126695,
  author="Hana {Uhlířová} and Kıvılcım {Kılıç} and Pfeifang {Tian} and Martin {Thunemann} and Michele {Desjardins} and Payam A. {Saisan} and Sava {Sakadžic} and Torbjørn V {Ness} and Celine {Mateo} and Qun {Cheng} and Kimberly L. {Weldy} and Florence {Razoux} and Matthieu {Vandenberghe} and Jonathan A {Cremonesi} and Christopher GL {Ferri} and Krystal {Nizar} and Vishnu B. {Sridhar} and Tyler C. {Steed} and Maxim {Abashin} and Yeshaiahu {Fainman} and Eliezer {Masliah} and Srdjan {Djurovic} and Ola A {Andreassen} and Gabriel A. {Silva} and David A. {Boas} and David {Kleinfeld} and Richard B {Buxton} and Gaute T. {Einevoll} and Anders M. {Dale} and Anna {Devor}",
  title="Cell type specificity of neurovascular coupling in cerebral cortex",
  journal="eLife",
  year="2016",
  volume="5",
  number="1",
  pages="1--23",
  doi="10.7554/elife.14315",
  issn="2050-084X",
  url="https://elifesciences.org/content/5/e14315"
}

Dokumenty

elife-14315-v2