Detail publikačního výsledku

Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli

DWIVEDI, G.; TIWARI, N.; SINGH, A.; KUMAR, A.; ROY, S.; NEGI, A.; PAL, A.; CHANDA, D.; SHARMA, A.; DAROKAR, M.

Originální název

Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli

Anglický název

Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli

Druh

Článek WoS

Originální abstrakt

The purpose of the present study was to study the synergy potential of gallic acid-based derivatives in combination with conventional antibiotics using multidrug resistant cultures of Escherichia coli. Gallic acid-based derivatives significantly reduced the MIC of tetracycline against multidrug resistant clinical isolate of E. coli. The best representative, 3-(3,4,5-trimethoxyphenyl)-4,5,6-trimethoxyindanone-1, an indanone derivative of gallic acid, was observed to inhibit ethidium bromide efflux and ATPase which was also supported by in silico docking. This derivative extended the post-antibiotic effect and decreased the mutation prevention concentration of tetracycline. This derivative in combination with TET was able to reduce the concentration of TNFα up to 18-fold in Swiss albino mice. This derivative was nontoxic and well tolerated up to 300 mg/kg dose in subacute oral toxicity study in mice. This is the first report of gallic acid-based indanone derivative as drug resistance reversal agent acting through ATP-dependent efflux pump inhibition.

Anglický abstrakt

The purpose of the present study was to study the synergy potential of gallic acid-based derivatives in combination with conventional antibiotics using multidrug resistant cultures of Escherichia coli. Gallic acid-based derivatives significantly reduced the MIC of tetracycline against multidrug resistant clinical isolate of E. coli. The best representative, 3-(3,4,5-trimethoxyphenyl)-4,5,6-trimethoxyindanone-1, an indanone derivative of gallic acid, was observed to inhibit ethidium bromide efflux and ATPase which was also supported by in silico docking. This derivative extended the post-antibiotic effect and decreased the mutation prevention concentration of tetracycline. This derivative in combination with TET was able to reduce the concentration of TNFα up to 18-fold in Swiss albino mice. This derivative was nontoxic and well tolerated up to 300 mg/kg dose in subacute oral toxicity study in mice. This is the first report of gallic acid-based indanone derivative as drug resistance reversal agent acting through ATP-dependent efflux pump inhibition.

Klíčová slova

Gallic acid, Indanone derivative, Efflux pump inhibition, Synergy, ATPase, Subacute oral toxicity

Klíčová slova v angličtině

Gallic acid, Indanone derivative, Efflux pump inhibition, Synergy, ATPase, Subacute oral toxicity

Autoři

DWIVEDI, G.; TIWARI, N.; SINGH, A.; KUMAR, A.; ROY, S.; NEGI, A.; PAL, A.; CHANDA, D.; SHARMA, A.; DAROKAR, M.

Rok RIV

2017

Vydáno

01.03.2016

Nakladatel

Springer-Verlag Berlin Heidelberg

Místo

Heidelberg

ISSN

0175-7598

Periodikum

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Svazek

100

Číslo

5

Stát

Spolková republika Německo

Strany od

2311

Strany do

2325

Strany počet

15

URL

http://link.springer.com/article/10.1007/s00253-015-7152-6

BibTex

@article{BUT121531,
  author="Guarav {Dwivedi} and Nimisha {Tiwari} and Aastha {Singh} and Akhil {Kumar} and Sudeep {Roy} and Arvind Singh {Negi} and Anirban {Pal} and Debabrata {Chanda} and Ashok {Sharma} and Mahendra {Darokar}",
  title="Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli",
  journal="APPLIED MICROBIOLOGY AND BIOTECHNOLOGY",
  year="2016",
  volume="100",
  number="5",
  pages="2311--2325",
  doi="10.1007/s00253-015-7152-6",
  issn="0175-7598",
  url="http://link.springer.com/article/10.1007/s00253-015-7152-6"
}