Detail výsledku s přesahem do praxe

Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber

ABDEL-LATTIF, A.; JANČÁŘ, J.

Originální název

Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber

Anglický název

Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber

Druh

Audiovizuální tvorba

Originální abstrakt

In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers for the first time. Sodium hyaluronate was dissolved in demineralized water to obtain good solution. Silver nitrate was added at ambient temperature, then the pH slightly was increased to 8 by adding few drops of sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers by wet-dry-spinning technique (WDST). The antibacterial performance of medical HA/AgNP fibers were evaluated against gram negative bacterial (E. coli), exhibiting excellent bactericidal activity. The fibers did not show any cytotoxicity against human keratinocyte cell line (HaCaT). In-vivo animal tests indicated that the prepared fiber dressing has excellent healing efficacy compared to the neat HA and greatly accelerated the healing process. Based on our results, the new HA/Ag nonwoven wound dressing can be used in treating wounds and chronic ulcers as well as cell carrier in different biological research and tissue engineering

Anglický abstrakt

In-situ formed hyaluronan/silver (HA/Ag) nanoparticles (NPs) were used to prepare composite fibers for the first time. Sodium hyaluronate was dissolved in demineralized water to obtain good solution. Silver nitrate was added at ambient temperature, then the pH slightly was increased to 8 by adding few drops of sodium hydroxide. The in-situ formed HA/Ag-NPs were used to prepare fibers by wet-dry-spinning technique (WDST). The antibacterial performance of medical HA/AgNP fibers were evaluated against gram negative bacterial (E. coli), exhibiting excellent bactericidal activity. The fibers did not show any cytotoxicity against human keratinocyte cell line (HaCaT). In-vivo animal tests indicated that the prepared fiber dressing has excellent healing efficacy compared to the neat HA and greatly accelerated the healing process. Based on our results, the new HA/Ag nonwoven wound dressing can be used in treating wounds and chronic ulcers as well as cell carrier in different biological research and tissue engineering

Klíčová slova

Hyaluronan, in-situ silver, cytotoxicity, wound dressing

Klíčová slova v angličtině

Hyaluronan, in-situ silver, cytotoxicity, wound dressing

Autoři

ABDEL-LATTIF, A.; JANČÁŘ, J.

Rok RIV

2017

Vydáno

17.10.2015

Nakladatel

Agnieszka Zarzycka

Místo

POLAND

Strany od

12

Strany do

12

Strany počet

1

BibTex

@misc{BUT118700,
  author="Abdelmohsen Moustafa {Abdellatif} and Josef {Jančář}",
  title="Wound Dressing Material Fabricated from Silver/Hyaluronan Bio-nanocomposite Fiber",
  year="2015",
  pages="12--12",
  publisher="Agnieszka Zarzycka",
  address="POLAND",
  note="Audiovisual work"
}