Detail publikačního výsledku

KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer

HOLUBOVÁ, M.; AXMANOVÁ, M.; GUMULEC, J.; RAUDENSKÁ, M.; SZTALMACHOVÁ, M.; BABULA, P.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Originální název

KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer

Anglický název

KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer

Druh

Článek WoS

Originální abstrakt

Zinc(II) ions are important components of many proteins and are involved in numerous cellular processes such as apoptosis or drug resistance. Prostate cancer has a unique relationship with zinc(II) ions. However, the relationship was examined only in short-term zinc(II) treatments. Therefore, the aim of this study was to create zinc-resistant prostatic cell lines at various stages of the disease (22Rv1 and PC-3) and a normal prostate epithelium (PNT1A) using a long-term zinc exposure.

Anglický abstrakt

Zinc(II) ions are important components of many proteins and are involved in numerous cellular processes such as apoptosis or drug resistance. Prostate cancer has a unique relationship with zinc(II) ions. However, the relationship was examined only in short-term zinc(II) treatments. Therefore, the aim of this study was to create zinc-resistant prostatic cell lines at various stages of the disease (22Rv1 and PC-3) and a normal prostate epithelium (PNT1A) using a long-term zinc exposure.

Klíčová slova

CITRATE METABOLISM; EPITHELIAL-CELLS; CARCINOMA-CELLS; DNA-DAMAGE; T-ANTIGEN; EXPRESSION; METALLOTHIONEIN; TRANSPORTER; APOPTOSIS; GENES

Klíčová slova v angličtině

CITRATE METABOLISM; EPITHELIAL-CELLS; CARCINOMA-CELLS; DNA-DAMAGE; T-ANTIGEN; EXPRESSION; METALLOTHIONEIN; TRANSPORTER; APOPTOSIS; GENES

Autoři

HOLUBOVÁ, M.; AXMANOVÁ, M.; GUMULEC, J.; RAUDENSKÁ, M.; SZTALMACHOVÁ, M.; BABULA, P.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Vydáno

01.07.2014

ISSN

1756-5901

Periodikum

Metallomics

Svazek

6

Číslo

7

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1240

Strany do

1253

Strany počet

14

BibTex

@article{BUT111196,
  author="Monika {Kratochvílová} and Martina {Axmanová} and Jaromír {Gumulec} and Martina {Raudenská} and Markéta {Svobodová} and Petr {Babula} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer",
  journal="Metallomics",
  year="2014",
  volume="6",
  number="7",
  pages="1240--1253",
  doi="10.1039/c4mt00065j",
  issn="1756-5901"
}