Detail publikačního výsledku

Colloid Properties of Ultrasound Contrast Agents

PILGROVÁ, T.; MRAVEC, F.; PEKAŘ, M.; HAVLÍNOVÁ, J.; ORBAN, M.

Originální název

Colloid Properties of Ultrasound Contrast Agents

Anglický název

Colloid Properties of Ultrasound Contrast Agents

Druh

Abstrakt

Originální abstrakt

Microbubbles are used in biomedical field as diagnostic agents in combination with ultrasound. This imaging technique has also been proposed for drug or gene delivery to targeted regions. The aim of our study was to identify the potential of ultrasound agent SonoVue(R) for drug delivery. The properties of SonoVue(R) were investigated by dynamic light scattering method, centrifugal dispersion analysis and fluorescence spectroscopy measurement. Ability of incorporation of drug was studied with doxorubicin hydrochloride and hydrophobic fluorescent probe. We present results of a pilot study to determine colloid properties of SonoVue(R) microbubble suspension. The results will be used in subsequent experiments and for design a new drug delivery system.

Anglický abstrakt

Microbubbles are used in biomedical field as diagnostic agents in combination with ultrasound. This imaging technique has also been proposed for drug or gene delivery to targeted regions. The aim of our study was to identify the potential of ultrasound agent SonoVue(R) for drug delivery. The properties of SonoVue(R) were investigated by dynamic light scattering method, centrifugal dispersion analysis and fluorescence spectroscopy measurement. Ability of incorporation of drug was studied with doxorubicin hydrochloride and hydrophobic fluorescent probe. We present results of a pilot study to determine colloid properties of SonoVue(R) microbubble suspension. The results will be used in subsequent experiments and for design a new drug delivery system.

Klíčová slova

microbubble, drug delivery, SonoVue(R)

Klíčová slova v angličtině

microbubble, drug delivery, SonoVue(R)

Autoři

PILGROVÁ, T.; MRAVEC, F.; PEKAŘ, M.; HAVLÍNOVÁ, J.; ORBAN, M.

Rok RIV

2014

Vydáno

05.09.2013

ISSN

1364-5706

Periodikum

MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES

Svazek

22

Číslo

1

Stát

Norské království

Strany od

46

Strany do

47

Strany počet

2

BibTex

@misc{BUT105632,
  author="Tereza {Pilgrová} and Filip {Mravec} and Miloslav {Pekař} and Jana {Havlínová} and Marek {Orban}",
  title="Colloid Properties of Ultrasound Contrast Agents",
  year="2013",
  journal="MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES",
  volume="22",
  number="1",
  pages="46--47",
  issn="1364-5706",
  note="Abstract"
}