Detail publikačního výsledku

The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters

BARTOŠ, M.; JIŘÍK, R.; KRATOCHVÍLA, J.; STANDARA, M.; STARČUK, Z.; TAXT, T.

Originální název

The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters

Anglický název

The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters

Druh

Článek WoS

Originální abstrakt

The present trend in dynamic contrast-Enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, the distributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated perfusion parameters can be described by the covariance matrix for signal-to-noise ratio higher than ~ 20 dB. The application of the new analysis model on a real DCE-MRI data set is also presented.

Anglický abstrakt

The present trend in dynamic contrast-Enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, the distributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated perfusion parameters can be described by the covariance matrix for signal-to-noise ratio higher than ~ 20 dB. The application of the new analysis model on a real DCE-MRI data set is also presented.

Klíčová slova

Dynamic contrast-enhanced MRI (DCE-MRI); perfusion; parameter estimation; bolus arrival time

Klíčová slova v angličtině

Dynamic contrast-enhanced MRI (DCE-MRI); perfusion; parameter estimation; bolus arrival time

Autoři

BARTOŠ, M.; JIŘÍK, R.; KRATOCHVÍLA, J.; STANDARA, M.; STARČUK, Z.; TAXT, T.

Rok RIV

2015

Vydáno

01.06.2014

Nakladatel

Elsevier

ISSN

0730-725X

Periodikum

MAGNETIC RESONANCE IMAGING

Svazek

32

Číslo

5

Stát

Spojené státy americké

Strany od

505

Strany do

513

Strany počet

9

BibTex

@article{BUT105502,
  author="Michal {Bartoš} and Radovan {Jiřík} and Jiří {Kratochvíla} and Michal {Standara} and Zenon {Starčuk} and Torfinn {Taxt}",
  title="The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters",
  journal="MAGNETIC RESONANCE IMAGING",
  year="2014",
  volume="32",
  number="5",
  pages="505--513",
  doi="10.1016/j.mri.2014.02.003",
  issn="0730-725X"
}