Biomechanical models tied to experiments represent decisive tools in investigating processes in living organs, tissues and cells. Cellular mechanical properties represent an important indicator for distinguishing between healthy and cancer cells, which can be exploited not only in research but also in cancer diagnostics and possibly therapy. The experimental application of mechanical stimuli for estimating these properties can be advantageously complemented by computational models to evaluate non-measurable quantities; especially due to the capability of structurebased Finite Element models to analyze the role of individual components in the cell mechanical responses. Their comprehensive validation is ensured by tailored experiments. Herein, the existing structure-based bendotensegrity Finite Element model will be enhanced to capture realistic cell geometry and structure, cellular adhesion and changes in actin fiber prestress. These features are deemed essential in the observed variances in mechanical properties between healthy and cancer cells and important in cancer metastasis.

Klíčová slova
Mechanical testing;finite element model;computational simulation;cancer cell;cytoskeleton modulation;

26-20714S

angličtina

Burša Jiří, prof. Ing., Ph.D. - hlavní řešitel

Ústav mechaniky těles, mechatroniky a biomechaniky
- odpovědné pracoviště (28.3.2025 - nezadáno)
Ústav mechaniky těles, mechatroniky a biomechaniky
- příjemce (28.3.2025 - nezadáno)

Odpovědnost: Burša Jiří, prof. Ing., Ph.D.