The Orthogonal Electrical Neuromodulation project aims to innovate bioelectronic medicine by advancing neuromodulation techniques beyond traditional electric-field effects. ORTHOMOD seeks to harness electrochemical reactions at the interface of implantable electrodes to modulate neural behavior with unprecedented precision, targeting complex neurochemical pathways. This approach promises significant improvements in the specificity and effectiveness of neuromodulation, providing a powerful tool for neuroscience as well as potential bioelectronic medicine. The project encompasses developing a faradaic electromodulation toolbox, creating novel neural interface hardware, validating new neuromodulation strategies in biological systems, and exploring wireless and minimally-invasive techniques based on nano/microtechnology. By integrating chemical mechanisms into neuromodulation, ORTHOMOD represents a paradigm shift towards more selective and nuanced use of electricity in biological interfaces.

Klíčová slova
Neuromodulation; electrochemistry; neural interface technology; neurostimulation; hypoxia

25-18184X

angličtina

Glowacki Eric Daniel, prof., Ph.D. - hlavní řešitel
Ehlich Jiří, Ing., Ph.D. - spoluřešitel
Jakešová Marie, Mgr., M.Sc., Ph.D. - spoluřešitel
Killinger Michael, Mgr., Ph.D., DiS. - spoluřešitel
Opančar Aleksandar, Ph.D. - spoluřešitel

Bioelektronické materiály a systémy
- odpovědné pracoviště (26.3.2024 - nezadáno)
Bioelektronické materiály a systémy
- příjemce (26.3.2024 - nezadáno)

OPANČAR, A.; ONDRÁČKOVÁ, P.; ROSE, D.; TRAJLINEK, J.; DEREK, V.; GLOWACKI, E. The same biophysical mechanism is involved in both temporal interference and direct kHz stimulation of peripheral nerves. Nature Communications, 2025, vol. 16, no. 1, p. 1-16.
Detail

TVRDOŇOVÁ, A.; JAKEŠOVÁ, M.; EHLICH, J.; GLOWACKI, E. Organic photovoltaic microburritos for photo(electro)catalytic peroxide generation. Chemical Communications, 2026, vol. 62, no. 4, p. 1293-1297.
Detail

Odpovědnost: Glowacki Eric Daniel, prof., Ph.D.