More extensive wounds at the oral mucosa site, especially after resection of oral tumors, are hard-to-heal. In this project, a bioresorbable, thermosensitive, and injectable copolymer based on lactic and glycolic acid and poly(ethylene glycol) PLGA-PEG-PLGA will be modified to promote mucoadhesive properties. The hydrogel will be further enriched with stabilized liposomal pro-healing protein (FGF2-STAB). The chemical structure, rheological properties, hydrolytic stability, and protein release of such a drug delivery system will be evaluated.

Popis anglicky
The aim of the project is to create a competition for student research grants and its pilot verification. The creation of a new competition will contribute to the development of cross-sectional skills of doctoral students, and thus acquire competencies for work in science and research in the future and increase their success in submitting scientific projects to national and international competitions.

Klíčová slova
Grant scheme, Project management, Doctoral study programmes, Research project, Competence at science and research

CEITEC VUT-K-22-7779

angličtina

Kadlecová Zuzana, Ing. - hlavní řešitel
Dzurov Matej, Ing., Ph.D. - spoluřešitel
Sevriugina Veronika, Ing. - spoluřešitel

Středoevropský technologický institut VUT
- odpovědné pracoviště (20.10.2021 - nezadáno)
Středoevropský technologický institut VUT
- příjemce (1.1.2022 - 31.12.2022)

KADLECOVÁ, Z.; CHAMRADOVÁ, I.; DINPARVAR, S.; HORÁKOVÁ, A.; KONEČNÁ, M.; ANGER, M.; VOJTOVÁ, L. Maximizing Bovine Embryo Survival and Development in vitro through Novel Biomimetic Hydrogel Cultivation. Vanajanlinna, Hämeenlinna, Finland: 2025. p. 17-17.
Detail

SEVRIUGINA, V.; KADLECOVÁ, Z.; VOJTOVÁ, L. The effect of liposomal pro-healing protein on the rheological properties of mucoadhesive injectable hydrogel. Program and Book of Abstracts. Materials Research Society of Serbia, 2022. p. 156-156. ISBN: 978-86-919111-7-1.
Detail

KADLECOVÁ, Z.; VOJTOVÁ, L. Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds. Czech Chemical Society Symposium Series. Czech Chemical Society, 2022. no. 1, p. 19-20. ISSN: 2336-7210.
Detail

KADLECOVÁ, Z.; DZUROV, M.; LYSÁKOVÁ, K.; VOJTOVÁ, L. Mucoadhesive Injectable Hydrogel Enriched with Encapsulated Pro-healing Protein for Hard-to-heal Oral Wounds Treatment. 32nd Annual Conference of the European Society for Biomaterials. France: Marjorie Dufaud, Member of the BIOMAT Young Researchers Board, 2022. p. 383-383.
Detail

Odpovědnost: Kadlecová Zuzana, Ing.