Detail publikačního výsledku

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

ZÍTKA, O.; SKALIČKOVÁ, S.; GUMULEC, J.; MASAŘÍK, M.; ADAM, V.; HUBÁLEK, J.; TRNKOVÁ, L.; KIZEK, R.

Originální název

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Anglický název

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Druh

Článek WoS

Originální abstrakt

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.

Anglický abstrakt

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.

Klíčová slova

glutathione, paediatric tumour patients, oxidative stress, high performance liquid chromatography with electrochemical detection

Klíčová slova v angličtině

glutathione, paediatric tumour patients, oxidative stress, high performance liquid chromatography with electrochemical detection

Autoři

ZÍTKA, O.; SKALIČKOVÁ, S.; GUMULEC, J.; MASAŘÍK, M.; ADAM, V.; HUBÁLEK, J.; TRNKOVÁ, L.; KIZEK, R.

Rok RIV

2013

Vydáno

01.10.2012

Nakladatel

SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE

Místo

Atény, Řecko

ISSN

1792-1082

Periodikum

Oncology Letters

Svazek

4

Číslo

4

Stát

Řecká republika

Strany od

1247

Strany do

1253

Strany počet

7

BibTex

@article{BUT95487,
  author="Ondřej {Zítka} and Sylvie {Skaličková} and Jaromír {Gumulec} and Michal {Masařík} and Vojtěch {Adam} and Jaromír {Hubálek} and Libuše {Trnková} and René {Kizek}",
  title="Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients",
  journal="Oncology Letters",
  year="2012",
  volume="4",
  number="4",
  pages="1247--1253",
  doi="10.3892/ol.2012.931",
  issn="1792-1074"
}