Detail publikačního výsledku

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

KŘÍŽKOVÁ,S.; MASAŘÍK,M.; KUKAČKA,J.; PRŮŠA,R.; ECKSCHLAGER,T., HUBALEK,J.; KIZEK,R.

Originální název

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

Anglický název

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

Druh

Abstrakt

Originální abstrakt

Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.

Anglický abstrakt

Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.

Klíčová slova

Metallothioneins (MTs), cytostatics, prostatic cancer

Klíčová slova v angličtině

Metallothioneins (MTs), cytostatics, prostatic cancer

Autoři

KŘÍŽKOVÁ,S.; MASAŘÍK,M.; KUKAČKA,J.; PRŮŠA,R.; ECKSCHLAGER,T., HUBALEK,J.; KIZEK,R.

Rok RIV

2013

Vydáno

26.07.2010

Nakladatel

EJC SUPPLEMENTS

Místo

Oslo, NORWAY

ISSN

1359-6349

Periodikum

EJC SUPPLEMENTS

Svazek

8

Číslo

5

Stát

Spojené království Velké Británie a Severního Irska

Strany od

49

Strany do

49

Strany počet

1

BibTex

@misc{BUT93598,
  author="KŘÍŽKOVÁ,S. and MASAŘÍK,M. and KUKAČKA,J. and PRŮŠA,R. and ECKSCHLAGER,T., HUBALEK,J. and KIZEK,R.",
  title="Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines",
  year="2010",
  journal="EJC SUPPLEMENTS",
  volume="8",
  number="5",
  pages="49--49",
  publisher="EJC SUPPLEMENTS",
  address="Oslo, NORWAY",
  issn="1359-6349",
  note="Abstract"
}