Detail publikačního výsledku

Cyclodextrin-Epichlorohydrin-Cyanoguanidine Polymer for Resveratrol Delivery to Enhance Human Chondrocyte Function in Cartilage Repair

ELMELIGY, M.; RASOULIAN, F.; KALANTARIFARD, S.; FILO, J.; DINPARVAR, S.; OMER, A.; VOJTOVÁ, L.; NEHRER, S.; LACIK, I.; HEYDARI, A.

Originální název

Cyclodextrin-Epichlorohydrin-Cyanoguanidine Polymer for Resveratrol Delivery to Enhance Human Chondrocyte Function in Cartilage Repair

Anglický název

Cyclodextrin-Epichlorohydrin-Cyanoguanidine Polymer for Resveratrol Delivery to Enhance Human Chondrocyte Function in Cartilage Repair

Druh

Článek WoS

Originální abstrakt

Water-soluble beta-cyclodextrin-epichlorohydrin polymers (CDPs) are widely used in drug delivery and regenerative medicine. Herein, we report a novel beta-cyclodextrin-epichlorohydrin-cyanoguanidine polymer (CDPC) for resveratrol (RES) delivery in cartilage repair. Cyanoguanidine (CyG), a nitrogen-rich compound remaining nonprotonated at physiological pH, was incorporated at varying CyG/beta-CD ratios to modulate the polymer properties. Structural characterization was performed by NMR, FT-IR, and CHN analyses. Compared with CDP, CDPC exhibited enhanced RES encapsulation that was attributed to additional intramolecular interactions. Dynamic light scattering revealed nanosized complexes (18 nm for CDPC/RES vs 4 nm for CDP/RES) with a near-neutral surface charge. CDPC showed intrinsic antioxidant activity, which was further enhanced upon RES loading. Both CDP and CDPC were cytocompatible and were efficiently internalized by human chondrocytes. Moreover, the CDP/RES and CDPC/RES systems improved the chondrocyte metabolic activity and extracellular matrix deposition, highlighting their potential as promising carriers for cartilage repair and regeneration.

Anglický abstrakt

Water-soluble beta-cyclodextrin-epichlorohydrin polymers (CDPs) are widely used in drug delivery and regenerative medicine. Herein, we report a novel beta-cyclodextrin-epichlorohydrin-cyanoguanidine polymer (CDPC) for resveratrol (RES) delivery in cartilage repair. Cyanoguanidine (CyG), a nitrogen-rich compound remaining nonprotonated at physiological pH, was incorporated at varying CyG/beta-CD ratios to modulate the polymer properties. Structural characterization was performed by NMR, FT-IR, and CHN analyses. Compared with CDP, CDPC exhibited enhanced RES encapsulation that was attributed to additional intramolecular interactions. Dynamic light scattering revealed nanosized complexes (18 nm for CDPC/RES vs 4 nm for CDP/RES) with a near-neutral surface charge. CDPC showed intrinsic antioxidant activity, which was further enhanced upon RES loading. Both CDP and CDPC were cytocompatible and were efficiently internalized by human chondrocytes. Moreover, the CDP/RES and CDPC/RES systems improved the chondrocyte metabolic activity and extracellular matrix deposition, highlighting their potential as promising carriers for cartilage repair and regeneration.

Klíčová slova

DRUG-DELIVERY; ENCAPSULATION; SOLUBILITY; DICYANDIAMIDE; CYCLODEXTRIN; RESVERATROL; POLYMERS; CARRIERS; SYSTEMS

Klíčová slova v angličtině

DRUG-DELIVERY; ENCAPSULATION; SOLUBILITY; DICYANDIAMIDE; CYCLODEXTRIN; RESVERATROL; POLYMERS; CARRIERS; SYSTEMS

Autoři

ELMELIGY, M.; RASOULIAN, F.; KALANTARIFARD, S.; FILO, J.; DINPARVAR, S.; OMER, A.; VOJTOVÁ, L.; NEHRER, S.; LACIK, I.; HEYDARI, A.

Vydáno

06.05.2026

Nakladatel

American Chemical Society

Periodikum

Biomacromolecules

Svazek

27

Číslo

5

Stát

Spojené státy americké

Strany od

3063

Strany do

3079

Strany počet

17

URL

https://pubs.acs.org/doi/10.1021/acs.biomac.5c02392

Plný text v Digitální knihovně

http://hdl.handle.net/11012/256523

BibTex

@article{BUT201993,
  author="{} and  {} and  {} and  {} and Sahar {Dinparvar} and  {} and Lucy {Vojtová} and  {} and  {} and Abolfazl {Heydari}",
  title="Cyclodextrin-Epichlorohydrin-Cyanoguanidine Polymer for Resveratrol Delivery to Enhance Human Chondrocyte Function in Cartilage Repair",
  journal="Biomacromolecules",
  year="2026",
  volume="27",
  number="5",
  pages="3063--3079",
  doi="10.1021/acs.biomac.5c02392",
  issn="1525-7797",
  url="https://pubs.acs.org/doi/10.1021/acs.biomac.5c02392"
}