Detail publikačního výsledku

Z-DNA interaction proteins - insights from ChIP-seq data

Dobrovolná M., Brázda V.

Originální název

Z-DNA interaction proteins - insights from ChIP-seq data

Anglický název

Z-DNA interaction proteins - insights from ChIP-seq data

Druh

Článek WoS

Originální abstrakt

Z-DNA is a noncanonical left-handed DNA conformation implicated in gene regulation and genome dynamics. Despite its biological relevance, the landscape of Z-DNA-binding proteins (ZBPs) in the human genome remains poorly characterized. In this study, we used the Z-Hunter algorithm to predict Z-DNA-forming sequences throughout the human genome. These predicted regions were then systematically overlaid with transcription factor (TF) binding profiles from the ChIP-Atlas database to identify proteins that co-localize with Z-DNA motifs. Our integrative analysis identified a diverse set of candidate ZBPs, including both known ZBP homologs and several TF, suggesting a broader regulatory role for Z-DNA in transcriptional control. This work provides a valuable resource for exploring the Z-DNA-protein interaction network and its potential implications for human health and disease.

Anglický abstrakt

Z-DNA is a noncanonical left-handed DNA conformation implicated in gene regulation and genome dynamics. Despite its biological relevance, the landscape of Z-DNA-binding proteins (ZBPs) in the human genome remains poorly characterized. In this study, we used the Z-Hunter algorithm to predict Z-DNA-forming sequences throughout the human genome. These predicted regions were then systematically overlaid with transcription factor (TF) binding profiles from the ChIP-Atlas database to identify proteins that co-localize with Z-DNA motifs. Our integrative analysis identified a diverse set of candidate ZBPs, including both known ZBP homologs and several TF, suggesting a broader regulatory role for Z-DNA in transcriptional control. This work provides a valuable resource for exploring the Z-DNA-protein interaction network and its potential implications for human health and disease.

Klíčová slova

Transcription factor, ChIP-seq, ChIP-atlas, Gene regulation, Bioinformatics

Klíčová slova v angličtině

Transcription factor, ChIP-seq, ChIP-atlas, Gene regulation, Bioinformatics

Autoři

Dobrovolná M., Brázda V.

Rok RIV

2026

Vydáno

19.11.2025

Periodikum

Biochemical and biophysical research communications

Číslo

790

Stát

Spojené státy americké

Strany počet

8

URL

https://www.sciencedirect.com/science/article/pii/S0006291X25016262?via%3Dihub

BibTex

@article{BUT200528,
  author="Michaela {Dobrovolná} and Václav {Brázda}",
  title="Z-DNA interaction proteins - insights from ChIP-seq data",
  journal="Biochemical and biophysical research communications",
  year="2025",
  number="790",
  pages="8",
  doi="10.1016/j.bbrc.2025.152910",
  issn="0006-291X",
  url="https://www.sciencedirect.com/science/article/pii/S0006291X25016262?via%3Dihub"
}