Detail publikačního výsledku

LA-ICP-MS for the analysis of essential element in stress-induced remodelled cardiac tissues

MACHALOVÁ, M.; STRAČINA, T.; VAŠINOVÁ GALIOVÁ, M.

Originální název

LA-ICP-MS for the analysis of essential element in stress-induced remodelled cardiac tissues

Anglický název

LA-ICP-MS for the analysis of essential element in stress-induced remodelled cardiac tissues

Druh

Konferenční sborník (ne stať)

Originální abstrakt

Long-term cardiac overload induces myocardial remodelling and collagen deposition, leading to irreversible myocardial fibrosis associated with heart failure. Because effective treatment is lacking, improved diagnostics and early prediction are crucial. This study employed LA-ICP-MS for 2D elemental imaging of rat heart tissue exposed to chronic stress, focusing on metals bound in metalloproteins involved in tissue remodelling. The distribution of Fe, Cu, and Zn showed elevated intensities and a positive correlation between Cu and Zn, suggesting altered metal homeostasis and protein expression during remodelling. These elemental changes may serve as potential indicators of myocardial damage and fibrosis development.

Anglický abstrakt

Long-term cardiac overload induces myocardial remodelling and collagen deposition, leading to irreversible myocardial fibrosis associated with heart failure. Because effective treatment is lacking, improved diagnostics and early prediction are crucial. This study employed LA-ICP-MS for 2D elemental imaging of rat heart tissue exposed to chronic stress, focusing on metals bound in metalloproteins involved in tissue remodelling. The distribution of Fe, Cu, and Zn showed elevated intensities and a positive correlation between Cu and Zn, suggesting altered metal homeostasis and protein expression during remodelling. These elemental changes may serve as potential indicators of myocardial damage and fibrosis development.

Autoři

MACHALOVÁ, M.; STRAČINA, T.; VAŠINOVÁ GALIOVÁ, M.

Vydáno

26.11.2025

Nakladatel

Fakulta chemickej a potravinárskej technológie

Místo

Bratislava

ISBN

978-80-8208-162

URL

https://zenodo.org/records/17647142

BibTex

@proceedings{BUT200488,
  editor="Martina {Machalová} and Tibor {Stračina} and Michaela {Vašinová Galiová}",
  title="LA-ICP-MS for the analysis of essential element in stress-induced remodelled cardiac tissues",
  year="2025",
  publisher="Fakulta chemickej a potravinárskej technológie",
  address="Bratislava",
  isbn="978-80-8208-162",
  url="https://zenodo.org/records/17647142"
}