Low-temperature sintered boron-doped S53P4 bioactive glass scaffolds fabricated by robocasting

Low-temperature sintered boron-doped S53P4 bioactive glass scaffolds fabricated by robocasting

Článek WoS

This study investigates boron-doped S53P4 bioactive glass (BG) scaffolds fabricated via robocasting in the context of bone regeneration strategies by comparing their mechanical performance and bioactive behavior to undoped S53P4 BG scaffolds. Three-dimensional scaffolds with grid-like macro architectures were fabricated using gelatin-based composite inks containing S53P4 BG and 10 wt.% boron-doped S53P4 BG (S53P4_10B). The scaffolds were sintered at optimized temperatures (900 degrees C for S53P4 and 615 degrees C for S53P4_10B), resulting in an average volumetric shrinkage of 33 vol%. Both scaffold types exhibited high porosity (similar to 71%) with pore sizes of 584 +/- 7 mu m (S53P4) and 608 +/- 25 mu m (S53P4_10B). Compressive strength values of 3.3 +/- 1.7 MPa and 1.5 +/- 0.4 MPa were respectively measured for S53P4 and for S53P4_10B BG scaffolds. Soaking in simulated body fluid for 14 days resulted in complete surface coverage with calcium-phosphate-rich phases, indicating high bioactivity. Antibacterial tests revealed that while crystallization reduced the inhibition zone of S53P4 scaffolds, S53P4_10B scaffolds exhibited significant antibacterial activity against E. coli and S. aureus. Cytocompatibility tests using MG-63 and ST-2 cell lines confirmed that scaffold extracts at concentrations

This study investigates boron-doped S53P4 bioactive glass (BG) scaffolds fabricated via robocasting in the context of bone regeneration strategies by comparing their mechanical performance and bioactive behavior to undoped S53P4 BG scaffolds. Three-dimensional scaffolds with grid-like macro architectures were fabricated using gelatin-based composite inks containing S53P4 BG and 10 wt.% boron-doped S53P4 BG (S53P4_10B). The scaffolds were sintered at optimized temperatures (900 degrees C for S53P4 and 615 degrees C for S53P4_10B), resulting in an average volumetric shrinkage of 33 vol%. Both scaffold types exhibited high porosity (similar to 71%) with pore sizes of 584 +/- 7 mu m (S53P4) and 608 +/- 25 mu m (S53P4_10B). Compressive strength values of 3.3 +/- 1.7 MPa and 1.5 +/- 0.4 MPa were respectively measured for S53P4 and for S53P4_10B BG scaffolds. Soaking in simulated body fluid for 14 days resulted in complete surface coverage with calcium-phosphate-rich phases, indicating high bioactivity. Antibacterial tests revealed that while crystallization reduced the inhibition zone of S53P4 scaffolds, S53P4_10B scaffolds exhibited significant antibacterial activity against E. coli and S. aureus. Cytocompatibility tests using MG-63 and ST-2 cell lines confirmed that scaffold extracts at concentrations

bioactive glass, bone-regeneration, robocasting, scaffold

bioactive glass, bone-regeneration, robocasting, scaffold

VARLIK, E.; DROTÁROVÁ, L.; OURGESSA, A.; VITAZKOVA, M.; NAWAZ, Q.; CHEN, S.; MONTUFAR JIMENEZ, E.; GALUSEK, D.; BOCCACCINI, A.; MICHALEK, M.

24.11.2025

Journal of the American Ceramic Society

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109

Spojené státy americké

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https://doi.org/10.1111/jace.70292