Detail publikačního výsledku

Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair

JU, X.; JAVORKOVÁ, E.; MICHALIČKA, J.; PUMERA, M.

Originální název

Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair

Anglický název

Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair

Druh

Článek WoS

Originální abstrakt

Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.

Anglický abstrakt

Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.

Klíčová slova

single-atom; cerium oxide; nanorobot; glucose; mesenchymal stem cells; cornea

Klíčová slova v angličtině

single-atom; cerium oxide; nanorobot; glucose; mesenchymal stem cells; cornea

Autoři

JU, X.; JAVORKOVÁ, E.; MICHALIČKA, J.; PUMERA, M.

Vydáno

13.05.2025

Nakladatel

American Chemical Society

Místo

WASHINGTON

ISSN

1936-086X

Periodikum

ACS Nano

Svazek

19

Číslo

20

Stát

Spojené státy americké

Strany od

19095

Strany do

19115

Strany počet

21

URL

https://pubs.acs.org/doi/10.1021/acsnano.4c18874

Plný text v Digitální knihovně

http://hdl.handle.net/11012/255199

BibTex

@article{BUT198219,
  author="Xiaohui {Ju} and Eliška {Javorková} and Jan {Michalička} and Martin {Pumera}",
  title="Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair",
  journal="ACS Nano",
  year="2025",
  volume="19",
  number="20",
  pages="19095--19115",
  doi="10.1021/acsnano.4c18874",
  issn="1936-0851",
  url="https://pubs.acs.org/doi/10.1021/acsnano.4c18874"
}

Dokumenty

ju-et-al-2025-single-atom-colloidal-nanorobotics-enhanced-stem-cell-therapy-for-corneal-injury-repair