Self-gated Arterial Spin Labeling Perfusion Mapping of Myocardium Using Magnetic Resonance Imaging

Self-gated Arterial Spin Labeling Perfusion Mapping of Myocardium Using Magnetic Resonance Imaging

Stať ve sborníku v databázi WoS či Scopus

Myocardial perfusion MR provides useful information for diagnosis of several cardiac diseases and allows for treatment monitoring. Many methods have been proposed based on DCE-MRI or ASL. With the current slow drift from contrast agent administration in clinical setup, it is necessary to develop reliable methods that would replace DCE-MRI. ASL has always been a hope for a clean noninvasive method of perfusion measurement, but due to its issues it is still not widely accepted as a reliable method especially outside of the brain. We propose a method for perfusion measurement based on FAIR-ASL which internally does not require ECG measurement, uses advanced acquisition tweaks and compressed sensing subspace image reconstruction. We test the method in a preclinical setup, where high B0 fields and higher heart rates are the main issues. The acquired flow maps were comparable with state of the art methods, while giving a possibility of acquisition shortening or increased spatial resolution. We were able to obtain perfusion maps of the whole cardiac cycle with 315 um spatial resolution and 1 mm slice thickness from a 15- minutes acquisition. The acquisition time could possibly be reduced further, by additional optimization of the pulse sequence.

Myocardial perfusion MR provides useful information for diagnosis of several cardiac diseases and allows for treatment monitoring. Many methods have been proposed based on DCE-MRI or ASL. With the current slow drift from contrast agent administration in clinical setup, it is necessary to develop reliable methods that would replace DCE-MRI. ASL has always been a hope for a clean noninvasive method of perfusion measurement, but due to its issues it is still not widely accepted as a reliable method especially outside of the brain. We propose a method for perfusion measurement based on FAIR-ASL which internally does not require ECG measurement, uses advanced acquisition tweaks and compressed sensing subspace image reconstruction. We test the method in a preclinical setup, where high B0 fields and higher heart rates are the main issues. The acquired flow maps were comparable with state of the art methods, while giving a possibility of acquisition shortening or increased spatial resolution. We were able to obtain perfusion maps of the whole cardiac cycle with 315 um spatial resolution and 1 mm slice thickness from a 15- minutes acquisition. The acquisition time could possibly be reduced further, by additional optimization of the pulse sequence.

ASL, MRI

ASL, MRI

VITOUŠ, J.; MACÍČEK, O.; JIŘÍK, R.

13.09.2024

Computing in Cardiology

CINC 2024

Computing in Cardiology

51

Spojené státy americké

4

https://cinc.org/archives/2024/pdf/CinC2024-345.pdf