Detail publikačního výsledku

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

MONTUFAR JIMENEZ, E.

Originální název

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

Anglický název

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

Druh

Článek WoS

Originální abstrakt

This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.

Anglický abstrakt

This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.

Klíčová slova

TUNGSTEN COILS; MECHANICAL-PROPERTIES; DEGRADABLE MAGNESIUM; HUMAN OSTEOBLASTS; VIVO; BIOCOMPATIBILITY; SCAFFOLDS; CELLS; ALLOYS; IRON

Klíčová slova v angličtině

TUNGSTEN COILS; MECHANICAL-PROPERTIES; DEGRADABLE MAGNESIUM; HUMAN OSTEOBLASTS; VIVO; BIOCOMPATIBILITY; SCAFFOLDS; CELLS; ALLOYS; IRON

Autoři

MONTUFAR JIMENEZ, E.

Vydáno

01.06.2025

Nakladatel

SPRINGER

Místo

NEW YORK

ISSN

1543-1851

Periodikum

JOM

Svazek

77

Číslo

6

Stát

Spojené státy americké

Strany od

4473

Strany do

4492

Strany počet

20

URL

https://link.springer.com/article/10.1007/s11837-025-07353-8

BibTex

@article{BUT197800,
  author="Edgar Benjamin {Montufar Jimenez}",
  title="Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility",
  journal="JOM",
  year="2025",
  volume="77",
  number="6",
  pages="4473--4492",
  doi="10.1007/s11837-025-07353-8",
  issn="1047-4838",
  url="https://link.springer.com/article/10.1007/s11837-025-07353-8"
}