Detail publikačního výsledku

BacSeqer: Read simulator for bacterial RNA-Seq

FIALOVÁ, A.; SEDLÁŘ, K.

Originální název

BacSeqer: Read simulator for bacterial RNA-Seq

Anglický název

BacSeqer: Read simulator for bacterial RNA-Seq

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

The RNA-Seq method has become a key tool in transcriptomics, providing deep insight into the genetic functioning of organisms. It is essential for understanding how genes are expressed, for discovering new gene variants and for understanding pathologies at the genetic level. RNA-Seq simulators are great for testing and validating bioinformatics tools, they offer a way to compare different computational algorithms and allow examining different sequencing protocols, parameter settings and sample sizes to ensure the most efficientuse of resources. This study introduces BacSeqer, an RNA-Seq simulator specifically designed for bacterial transcriptomes with the aim of producing data that faithfully resembles those obtained in real experiments. It allows to take into account the specificities of the bacterial genome, especially an existence of only exons and their organization in operons that are not normally present in eukaryotes.

Anglický abstrakt

The RNA-Seq method has become a key tool in transcriptomics, providing deep insight into the genetic functioning of organisms. It is essential for understanding how genes are expressed, for discovering new gene variants and for understanding pathologies at the genetic level. RNA-Seq simulators are great for testing and validating bioinformatics tools, they offer a way to compare different computational algorithms and allow examining different sequencing protocols, parameter settings and sample sizes to ensure the most efficientuse of resources. This study introduces BacSeqer, an RNA-Seq simulator specifically designed for bacterial transcriptomes with the aim of producing data that faithfully resembles those obtained in real experiments. It allows to take into account the specificities of the bacterial genome, especially an existence of only exons and their organization in operons that are not normally present in eukaryotes.

Klíčová slova

RNA-Seq; simulation; sequencing; bacteria; gene expression

Klíčová slova v angličtině

RNA-Seq; simulation; sequencing; bacteria; gene expression

Autoři

FIALOVÁ, A.; SEDLÁŘ, K.

Rok RIV

2025

Vydáno

24.04.2024

ISBN

978-80-214-6230-4

Kniha

Proceedings II of the 30 th Conference STUDENT EEICT 2024

Edice

1

Strany od

12

Strany do

15

Strany počet

4

BibTex

@inproceedings{BUT189095,
  author="Adéla {Fialová} and Karel {Sedlář}",
  title="BacSeqer: Read simulator for bacterial RNA-Seq",
  booktitle="Proceedings II of the 30 th Conference STUDENT EEICT 2024",
  year="2024",
  series="1",
  pages="12--15",
  isbn="978-80-214-6230-4"
}