Detail publikace

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

SIEMASZKO, J. MARZEC-PRZYSZLAK, A. BOGUNIA-KUBIK, K.

Originální název

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies. It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection. Additionally, the authors attempt to shed some light on receptor’s unique interaction with its ligand which is shared with another receptor (CD94/NKG2A) with rather opposite properties.

Klíčová slova

NK cell receptors;immunotherapy;ligand

Autoři

SIEMASZKO, J.; MARZEC-PRZYSZLAK, A.; BOGUNIA-KUBIK, K.

Vydáno

10. 3. 2023

Nakladatel

Springer Nature

Místo

Switzerland

ISSN

0004-069X

Periodikum

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Ročník

71

Číslo

1

Stát

Polská republika

Strany od

1

Strany do

18

Strany počet

18

URL

https://link.springer.com/article/10.1007/s00005-023-00674-z

Plný text v Digitální knihovně

http://hdl.handle.net/11012/213623

BibTex

@article{BUT183147,
  author="Jagoda {Siemaszko} and Aleksandra {Marzec-Przyszlak} and Katarzyna {Bogunia-Kubik}",
  title="Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications",
  journal="ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS",
  year="2023",
  volume="71",
  number="1",
  pages="1--18",
  doi="10.1007/s00005-023-00674-z",
  issn="0004-069X",
  url="https://link.springer.com/article/10.1007/s00005-023-00674-z"
}