Detail publikačního výsledku

Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks

RAYMOND, S.; MAAZOUZ, Y.; MONTUFAR JIMENEZ, E.; PEREZ, R. A.; GONZALEZ, B.; KONKA J.; KAISER, J.; GINEBRA, M. P.

Originální název

Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks

Anglický název

Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks

Druh

Článek WoS

Originální abstrakt

Direct ink writing (DIW) techniques open up new possibilities for the fabrication of patient-specific bone grafts. Self-setting calcium phosphate inks, which harden at low temperature, allow obtaining nanostructured scaffolds with biomimetic properties and enhanced bioactivity. However, the slow hardening kinetics hampers the translation to the clinics. Different hydrothermal treatments for the consolidation of DIW scaffolds fabricated with an a-tricalcium phosphate /pluronic F127 ink were explored, comparing them with a biomimetic treatment. Three different scaffold architectures were analysed. The hardening process, associated to the conversion of a-tricalcium phosphate to hydroxyapatite was drastically accelerated by the hydrothermal treatments, reducing the time for complete reaction from 7 days to 30 minutes, while preserving the scaffold architectural integrity and retaining the nanostructured features. b-tricalcium phosphate was formed as a secondary phase, and a change of morphology from plate-like to needle-like crystals in the hydroxyapatite phase was observed. The binder was largely released during the treatment. The hydrothermal treatment resulted in a 30% reduction of the compressive strength, associated to the residual presence of b-tricalcium phosphate. Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications.

Anglický abstrakt

Direct ink writing (DIW) techniques open up new possibilities for the fabrication of patient-specific bone grafts. Self-setting calcium phosphate inks, which harden at low temperature, allow obtaining nanostructured scaffolds with biomimetic properties and enhanced bioactivity. However, the slow hardening kinetics hampers the translation to the clinics. Different hydrothermal treatments for the consolidation of DIW scaffolds fabricated with an a-tricalcium phosphate /pluronic F127 ink were explored, comparing them with a biomimetic treatment. Three different scaffold architectures were analysed. The hardening process, associated to the conversion of a-tricalcium phosphate to hydroxyapatite was drastically accelerated by the hydrothermal treatments, reducing the time for complete reaction from 7 days to 30 minutes, while preserving the scaffold architectural integrity and retaining the nanostructured features. b-tricalcium phosphate was formed as a secondary phase, and a change of morphology from plate-like to needle-like crystals in the hydroxyapatite phase was observed. The binder was largely released during the treatment. The hydrothermal treatment resulted in a 30% reduction of the compressive strength, associated to the residual presence of b-tricalcium phosphate. Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications.

Klíčová slova

Calcium phosphate; Hydroxyapatite; Biomimetic; Bone regeneration; 3D plotting; Direct ink writing; Bone graft

Klíčová slova v angličtině

Calcium phosphate; Hydroxyapatite; Biomimetic; Bone regeneration; 3D plotting; Direct ink writing; Bone graft

Autoři

RAYMOND, S.; MAAZOUZ, Y.; MONTUFAR JIMENEZ, E.; PEREZ, R. A.; GONZALEZ, B.; KONKA J.; KAISER, J.; GINEBRA, M. P.

Rok RIV

2019

Vydáno

15.06.2018

Nakladatel

Elsevier

Místo

England

ISSN

1742-7061

Periodikum

Acta Biomaterialia

Svazek

1

Číslo

75

Stát

Spojené království Velké Británie a Severního Irska

Strany od

451

Strany do

462

Strany počet

12

URL

https://doi.org/10.1016/j.actbio.2018.05.042

BibTex

@article{BUT149366,
  author="RAYMOND, S. and MAAZOUZ, Y. and MONTUFAR JIMENEZ, E. and PEREZ, R. A. and GONZALEZ, B. and KONKA J. and KAISER, J. and GINEBRA, M. P.",
  title="Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks",
  journal="Acta Biomaterialia",
  year="2018",
  volume="1",
  number="75",
  pages="451--462",
  doi="10.1016/j.actbio.2018.05.042",
  issn="1742-7061",
  url="https://doi.org/10.1016/j.actbio.2018.05.042"
}