Detail publikačního výsledku

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

STRAČINA, T.; RONZHINA, M.; STARK, T.; RUDA, J.; OLŠANSKÁ, E.; VESELÝ, P.; MICALE, V.; NOVÁKOVÁ, M.

Originální název

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

Anglický název

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.

Anglický abstrakt

QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.

Klíčová slova

Rat isolated heart; electrogram; QT interval; heart rate; arrhythmia; schizophrenia; haloperidol

Klíčová slova v angličtině

Rat isolated heart; electrogram; QT interval; heart rate; arrhythmia; schizophrenia; haloperidol

Autoři

STRAČINA, T.; RONZHINA, M.; STARK, T.; RUDA, J.; OLŠANSKÁ, E.; VESELÝ, P.; MICALE, V.; NOVÁKOVÁ, M.

Rok RIV

2017

Vydáno

15.11.2016

ISBN

978-1-5090-0895-7

Kniha

Computing in Cardiology Conference

Strany od

1049

Strany do

1052

Strany počet

4

URL

https://ieeexplore.ieee.org/document/7868926

BibTex

@inproceedings{BUT129342,
  author="Tibor {Stračina} and Marina {Filipenská} and Tibor {Stark} and Jana {Ruda} and Eva {Olšanská} and Petr {Veselý} and Vincenzo {Micale} and Marie {Nováková}",
  title="Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia",
  booktitle="Computing in Cardiology Conference",
  year="2016",
  number="43",
  pages="1049--1052",
  isbn="978-1-5090-0895-7",
  url="https://ieeexplore.ieee.org/document/7868926"
}